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首页> 外文期刊>Artificial Organs >Baroreflex sensitivity of an arterial wall during rotary blood pump assistance.
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Baroreflex sensitivity of an arterial wall during rotary blood pump assistance.

机译：旋转血泵辅助期间动脉壁的压力反射敏感性。

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It is well known that the baroreflex system is one of the most important indicators of the pathophysiology in hypertensive patients. We can check the sensitivity of the baroreflex by observing heart rate (HR) responses; however, there is no simple diagnostic method to measure the arterial behavior in the baroreflex system. Presently, we report the development of a method and associated hardware that enables the diagnosis of baroreflex sensitivity by measuring the responses of both the heart and the artery. In this system, the measurements are obtained by monitoring an electrocardiogram and a pulse wave recorded from the radial artery or fingertip. The arterial responses were measured in terms of the pulse wave velocity (PWV) calculated from the pulse wave transmission time (PTT) from the heart to the artery. In this system, the HR change corresponding to the blood pressure change in time series sequence was observed. Slope of the changes in blood pressure and HR indicated the sensitivity of the baroreflex system of the heart. This system could also measure the sensitivity of the baroreflex system of an artery. Changes in the PWV in response to the blood pressure changes were observed. Significant correlation was observed in the time sequence between blood pressure change and PWV change after calculating the delay time by cross-correlation. The slope of these parameter changes was easily obtained and it demonstrated the sensitivity of the baroreflex system of an artery. We evaluated this method in animal experiments using rotary blood pump (RBP) with undulation pump ventricular assist device, and PTT elongation was observed in response to increased blood pressure with RBP assistance. Furthermore, when tested clinically, decreased sensitivity of the baroreflex system in hypertensive patients was observed. This system may be useful when we consider the ideal treatment and follow-up of patients with hypertension.
机译：众所周知，压力反射系统是高血压患者病理生理的最重要指标之一。我们可以通过观察心律（HR）反应来检查压力反射的敏感性。然而，没有简单的诊断方法可以测量压力反射系统中的动脉行为。目前，我们报告了一种方法和相关硬件的开发，该方法和相关硬件通过测量心脏和动脉的反应来诊断压力反射敏感性。在该系统中，通过监视心电图和从the动脉或指尖记录的脉搏波来获得测量值。根据从心脏到动脉的脉搏波传播时间（PTT）计算出的脉搏波速度（PWV）来测量动脉反应。在该系统中，观察到与血压在时间序列上的变化相对应的HR变化。血压和HR变化的斜率表明了心脏压力反射系统的敏感性。该系统还可以测量动脉的压力反射系统的灵敏度。观察到响应于血压变化的PWV变化。通过互相关计算延迟时间后，在血压变化和PWV变化之间的时间序列中观察到显着的相关性。这些参数变化的斜率很容易获得，证明了动脉压力反射系统的敏感性。我们在带有动静脉泵心室辅助装置的旋转式血泵（RBP）的动物实验中评估了该方法，并且在RBP辅助下响应血压升高观察到PTT伸长。此外，当进行临床测试时，在高血压患者中发现压力反射系统的敏感性降低。当我们考虑对高血压患者进行理想的治疗和随访时，该系统可能会有用。

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