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首页> 外文期刊>Asia-Pacific journal of clinical oncology >Management of tumor lysis syndrome with a single fixed dose of rasburicase in Asian lymphoma patients: a case series and literature review.
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Management of tumor lysis syndrome with a single fixed dose of rasburicase in Asian lymphoma patients: a case series and literature review.

机译：在亚洲淋巴瘤患者中使用单一固定剂量的rasburicase治疗肿瘤溶解综合征：一个病例系列和文献综述。

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AIM: Recently, a number of studies have demonstrated the effectiveness of a single reduced dose of rasburicase for the management of tumor lysis syndrome (TLS) in adults. Whether Asian lymphoma patients similarly respond to a single dose of rasburicase is currently unknown. We aim to assess the efficacy of a single dose rasburicase in preventing TLS in Asian lymphoma patients. METHODS: This was a single-center case series of adult lymphoma patients at high risk of TLS who received a single fixed dose of rasburicase. Patients had to have their uric acid, serum creatinine, lactate dehydrogenase and electrolytes monitored for at least 24-48 h post-administration. RESULTS: Eleven patients were identified. Majority were Chinese (91%), male (64%) and with a median age of 61 years (range 41-84). All had at least two risk factors for developing TLS. Ten patients received a 6-mg dose and one received 4.5 mg. Prior to rasburicase administration, the mean uric acid level was 835 micromol/L (range 318-1237 micromol/L) and the level 24-h post-administration was 186 micromol/L (range 30-653 micromol/L) (P < 0.001). Eight patients (73%) experienced an improvement of renal function 72-h post-rasburicase. Normalization of serum electrolytes was achieved within 96 h. CONCLUSION: Among Asian lymphoma patients who manifested at least two risk factors for developing TLS, a single fixed dose of rasburicase at 6 mg is deemed to be effective for rapidly lowering uric acid levels as well as sustaining reduced levels for up to 72 h.
机译：目的：最近，许多研究表明，单次减少剂量的葡萄干酶治疗成人肿瘤溶解综合征（TLS）的有效性。目前尚不清楚亚洲淋巴瘤患者是否对单剂量的芥酸酶有类似反应。我们旨在评估单剂量rasburicase预防亚洲淋巴瘤患者TLS的疗效。方法：这是一例单中心病例的成年TLS高危成人淋巴瘤患者，他们接受了固定剂量的rasburicase。给药后至少24-48小时必须监测患者的尿酸，血清肌酐，乳酸脱氢酶和电解质。结果：确定了11例患者。多数为中国人（91％），男性（64％），中位年龄为61岁（范围41-84）。所有人都有至少两个发展TLS的风险因素。 10名患者接受6毫克剂量，而一名患者接受4.5毫克剂量。施用芥酸酶之前，平均尿酸水平为835 micromol / L（范围318-1237 micromol / L），给药后24小时的水平为186 micromol / L（范围30-653 micromol / L）（P < 0.001）。 8例（73％）患者在使用芥酸酶治疗72小时后肾功能有所改善。血清电解质正常化在96小时内完成。结论：在表现出至少两种发展为TLS的危险因素的亚洲淋巴瘤患者中，单次固定剂量的6mg葡萄干酶被认为可有效快速降低尿酸水平并维持降低的水平长达72小时。

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