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首页> 外文期刊>Asian journal of drug metabolism and pharmacokinetics >Overview of factors affecting oral drug absorption
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Overview of factors affecting oral drug absorption

机译：影响口服药物吸收的因素概述

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摘要

This article provides an overview of variables that can affect drug absorption following oral administration in recent years, including both physicochemical properties of the drug and physiological factors of the body. The oral absorption of a drug is a complex process depending upon these factors and their interactions with each other. Solubility and permeability are considered as the major physicochemical factor that affect the rate and extent of oral drug absorption, moreover other physicochemical properties always show their effects to drug absorption via affecting solubility and permeability. In this regard, the Biopharmaceutics Classification System is proved to be a successful predictive tool for drug development. Oral drug bioavailability can also be markedly influenced by physiological factors, such as gastrointestinal pH, gastric emptying, small intestinal transit time, bile salt, absorption mechanism and so on. Thus by understanding the physicochemical properties of a compound and by recognizing the physiological processe affecting drug absorption, also with the awareness of a drug's BCS characteristics, pharmaceutical scientists can better predict drug absorption and develop formulations that can maximize drug bioavailability.
机译：本文概述了近年来影响口服后药物吸收的变量，包括药物的理化性质和身体的生理因素。药物的口服吸收是一个复杂的过程，取决于这些因素及其相互之间的相互作用。溶解度和渗透性被认为是影响口服药物吸收速率和程度的主要物理化学因素，此外，其他物理化学性质也总是通过影响溶解度和渗透性而显示出它们对药物吸收的影响。在这方面，事实证明，生物制药分类系统是药物开发的成功预测工具。口服药物的生物利用度也可能受到生理因素的显着影响，例如胃肠道pH，胃排空，小肠运输时间，胆汁盐，吸收机制等。因此，通过了解化合物的物理化学性质并认识到影响药物吸收的生理过程，并且也意识到药物的BCS特性，药物科学家可以更好地预测药物吸收并开发可最大化药物生物利用度的制剂。

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