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首页> 外文期刊>Annals of Human Genetics >Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain).
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Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain).

机译：Pasiegos（来自坎塔布里亚（西班牙）的人类分离株）的Y染色体和线粒体DNA特征。

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摘要

Mitochondrial DNA sequences and Y chromosome haplotypes were characterized in Pasiegos, a human isolate from Cantabria, and compared with those of other Cantabrian and neighbouring Northern Spain populations. Cantabria appears to be a genetically heterogeneous community. Whereas Lebaniegos do not differ from their eastern Basque and western Asturian and Galician neighbours, Pasiegos and other non-Lebaniego Cantabrians show significant differences with all of them. Pasiegos are peculiar for their high frequencies of Y chromosomal markers (E-M81) with North African assignation, and Y chromosomal (R-SRY2627) and mtDNA (V, I, U5) markers related to northern European populations. This dual geographic contribution is more in agreement with the complex demographic history of this isolate, as opposed to recent drift effects. The high incidence in Cantabrians with pre-V and V mtDNA haplotypes, considered as a signal of Postglacial recolonization in Europe from south-western refugees, points to such refugees as a better candidate population than Basques for this expansion. However, this does not discount a conjoint recolonization.
机译：在来自坎塔布里亚的人类分离株Pasiegos中表征了线粒体DNA序列和Y染色体单倍型，并与其他坎塔布连和西班牙北部居民进行了比较。坎塔布里亚似乎是一个遗传异质的群落。黎巴嫩人与东部的巴斯克人以及阿斯图里亚斯人和加利西亚人的西方人没有什么不同，而帕西戈斯人和其他非黎巴嫩人的坎塔布连人之间却有很大的不同。 Pasiegos因其具有北非归属的Y染色体标记（E-M81）和与北欧人群有关的Y染色体（R-SRY2627）和mtDNA（V，I，U5）标记的频率高而特别。与最近的漂移效应相反，这种双重地理贡献与该隔离区的复杂人口历史更加吻合。具有前V和V mtDNA单倍型的坎塔布连人的高发病率，被认为是欧洲西南难民在欧洲后冰封殖民化的信号，表明这种难民比巴斯克人更适合这种扩张。但是，这不会减少联合重新殖民化。

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