On extending the transmission/disequilibrium test (TDT).

Wilson SR

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On extending the transmission/disequilibrium test (TDT).

机译：关于扩展传输/不平衡测试（TDT）。

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The transmission/disequilibrium test (TDT), for evaluation of the null hypothesis of neither linkage nor association between a marker locus and disease, is extended to the more general situation of transmission of two multi-allele marker loci from parents to affected offspring. Transmission probabilities are derived for a generalized single locus disease model, where the disease locus is taken to lie between the two marker loci. There could be unlinked modifier loci for the disease. Examples of the extended TDT are given and it is shown how the contribution from each locus can be evaluated, both separately and jointly.

机译：用于评估标记基因座与疾病之间既没有联系也没有关联的无效假设的传递/不平衡检验（TDT）扩展到了两个多等位基因标记基因座从父母传给患病后代的更一般情况。传播概率是针对广义的单基因座疾病模型得出的，该疾病的基因座位于两个标记基因座之间。该疾病可能有未关联的修饰位点。给出了扩展TDT的示例，并显示了如何分别或联合评估每个基因座的贡献。

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《Annals of Human Genetics》 |1997年第2期|共11页
作者
Wilson SR;
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正文语种 eng
中图分类遗传学;
关键词
Linkage Disequilibrium; Genetic Markers; 连锁不平衡;

机译：Linkage Disequilibrium;Genetic Markers;连锁不平衡;

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专利

1. On extending the transmission/disequilibrium test (TDT). [J] . Wilson SR Annals of Human Genetics . 1997,第Pta2期

机译：关于扩展传输/不平衡测试（TDT）。
2. TDT-HET: A new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data [J] . Douglas Londono, Steven Buyske, Stephen J Finch, BMC Bioinformatics . 2012,第1期

机译：TDT-HET：一种新的传播不平衡测试，将基因座异质性纳入基于家庭的关联数据分析中
3. Transmission Disequilibrium Test (TDT) for a pair of linked marker loci [J] . Narain P Computational statistics & data analysis . 2009,第5期

机译：一对连锁标记基因座的传输不平衡测试（TDT）
4. Statistical aspects of the transmission/disequilibrium test (TDT) [C] . Warren J. Ewens Joint AMS-IMS-SIAM Summer Conference on Statistics in Molecular Biology . 1999

机译：透射/不平衡测试（TDT）的统计方面
5. Theory and application methods of time domain reflectometry/time domain transmission computed tomography (TDR/TDT CT). [D] . Li, Jian. 2007

机译：时域反射仪/时域透射计算机断层扫描（TDR / TDT CT）的理论和应用方法。
6. TDT-HET: A new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data [O] . Douglas Londono, Steven Buyske, Stephen J Finch, 2012

机译：TDT-HET：一种新的传播不平衡测试将基因座异质性纳入基于家庭的关联数据分析中
7. Sample Sizes For The Transmission Disequilibrium Tests: Tdt, S-Tdt And 1-Tdt [O] . Dai Wang, Fengzhu Sun 2000

机译：传输不平衡测试的样本量：Tdt，S-Tdt和1-Tdt
8. Linkage Disequilibrium of HLA-SB1 with the HLA-A1, B8, DR3, SC01 and of HLA-SB4 with the HLA-A26, Bw38, Dw10, DR4, SC21 Extended Haplotypes [R] . Matsui, Y., Alosco, S. M., Awdeh, Z., 1984

机译：HLa-sB1与HLa-a1，B8，DR3，sC01和HLa-sB4与HLa-a26，Bw38，Dw10，DR4，sC21扩展单倍型的连锁不平衡

On extending the transmission/disequilibrium test (TDT).

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