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首页> 外文期刊>Annals of Human Genetics >Contrasting patterns of nuclear and mtDNA diversity in Native American populations.
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Contrasting patterns of nuclear and mtDNA diversity in Native American populations.

机译：美洲原住民群体中核和mtDNA多样性的对比模式。

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摘要

We report an integrated analysis of nuclear (autosomal, X- and Y-chromosome) short tandem repeat (STR) data and mtDNA D-loop sequences obtained in the same set of 22 Native populations from across the Americas. A north to south gradient of decreasing population diversity was observed, in agreement with a settlement of the Americas from the extreme northwest of the continent. This correlation is stronger with "least cost distances," which consider the coasts as facilitators of migration. Continent-wide estimates of population structure are highest for the Y-chromosome and lowest for the autosomes, consistent with the effective size of the different marker systems examined. Population differentiation is highest in East South America and lowest in Meso America and the Andean region. Regional analyses suggest a deviation from mutation-drift equilibrium consistent with population expansion in Meso America and the Andes and population contraction in Northwest and East South America. These data hint at an early divergence of Andean and non-Andean South Americans and at a contrasting demographic history for populations from these regions.
机译：我们报告了核（常染色体，X和Y染色体）短串联重复序列（STR）数据和mtDNA D环序列的综合分析，这些数据是从美洲的22个本地居民的同一组中获得的。观察到人口多样性从北向南倾斜，这与该大陆最西北部的美洲定居点相符。这种相关性在“最低成本距离”下更强，“最低成本距离”将海岸视为移民的促进因素。整个大陆的人口结构估计值，Y染色体最高，常染色体最低，与所研究的不同标记系统的有效大小一致。人口分化在南美东部最高，在中美美洲和安第斯地区最低。区域分析表明，偏离突变漂移均衡与中美美洲和安第斯山脉的人口膨胀以及西北和南美东部的人口收缩相一致。这些数据表明，安第斯和非安第斯南美人之间早有分歧，而且这些地区的人口统计学历史也不同。

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