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首页> 外文期刊>Annals of Human Genetics >Mitochondrial DNA Variation in Mauritania and Mali and their Genetic Relationship to Other Western Africa Populations
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Mitochondrial DNA Variation in Mauritania and Mali and their Genetic Relationship to Other Western Africa Populations

机译：毛里塔尼亚和马里的线粒体DNA变异及其与其他西非人群的遗传关系

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摘要

Mitochondrial DNA (mtDNA) variation was analyzed in Mauritania and Mali, and compared to other West African samples covering the considerable geographic, ethnic and linguistic diversity of this region,. The Mauritanian mtDNA profile shows that 55% of their lineages have a west Eurasian provenance, with the U6 cluster (17%) being the best represented. Only 6% of the sub-Saharan sequences belong to the L.3A haplogroup a frequency similar to other Berber speaking groups but significantly different to the Arabic speaking North Africans, The historic Arab slave trade may be the main cause of this difference. Only one HV west Eurasian lineage has been detected in Mali but 40% of the sub-Saharan sequences belong to cluster L3A. The presence of LOa representatives demonstrates gene flow from eastern regions. Although both groups speak related dialects of the Mande branch, significant genetic differences exist between the Bambara and Malinke groups The West African genetic variation is well structured by geography and language, but more detailed ethnolinguistic clustering suggest that geography is the main factor responsible for this differentiation.
机译：分析了毛里塔尼亚和马里的线粒体DNA（mtDNA）变异，并将其与其他西非样本进行了比较，这些样本涵盖了该地区相当大的地理，种族和语言多样性。毛里塔尼亚的mtDNA谱显示，他们的血统中有55％具有西欧亚血统，其中U6簇（17％）是最能代表的。撒哈拉以南亚序列中只有6％属于L.3A单倍群，其频率与其他柏柏尔语群体相似，但与阿拉伯语北非人明显不同。历史悠久的阿拉伯奴隶贸易可能是造成这种差异的主要原因。在马里仅检测到一个HV西欧亚大陆谱系，但40％的撒哈拉以南亚序列属于类群L3A。 LOa代表的存在证明了来自东部地区的基因流。尽管这两个族群都讲Mande支的相关方言，但班巴拉族和马林克族之间存在重大的遗传差异。西非的遗传变异在地理和语言上都具有良好的结构，但是更详细的民族语言聚类表明，地理是造成这种分化的主要因素。

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