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首页> 外文期刊>Atherosclerosis >Associations of very high C-reactive protein concentration with psychosocial and cardiovascular risk factors in an ageing population.
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Associations of very high C-reactive protein concentration with psychosocial and cardiovascular risk factors in an ageing population.

机译：老年人群中很高的C反应蛋白浓度与社会心理和心血管危险因素的关系。

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摘要

BACKGROUND: Raised levels of C-reactive protein (CRP), a marker of low grade systemic inflammation, is common in ageing populations although the relevance of very highly elevated CRP (>10mg/L) remains unclear. We examined cross-sectional associations of very high CRP with psychosocial, behavioural, and cardiovascular risk factors. METHODS: Participants were 5307 men and women from the English Longitudinal Study of Ageing, a study of community dwelling older adults (46.0% men, aged 66.5+/-10.1 years). Psychosocial (social status, marital status, depressive symptoms), behavioural (smoking, physical activity, alcohol), and cardiovascular risk factors (blood pressure, cholesterol, glycated haemoglobin, body mass index, waist) were assessed in relation to CRP. RESULTS: A very high CRP concentration was recorded in 7.5% of the sample. After adjustments for age, sex, acute infection and chronic inflammatory conditions, very high CRP was associated with lower social position, depressive symptoms, physical inactivity, smoking, and alcohol abstinence. There was a linear trend for increased prevalence of cardiovascular risk factors across CRP categories representing low (<1mg/L), medium (1 to <3mg/L), high (3-10mg/L), and very high (>10mg/L), although little differences in risk between high and very high groups were observed. CONCLUSIONS: Very high levels of CRP in elderly participants might reflect chronic health and psychosocial adversity, independently of acute infection.
机译：背景：C反应蛋白（CRP）水平升高是低度全身性炎症的标志，在老年人群中很常见，尽管仍不清楚高度升高的CRP（> 10mg / L）的相关性。我们检查了高CRP与社会心理，行为和心血管危险因素的横断面关联。方法：参加者是来自英国纵向老龄化研究的5307名男性和女性，该研究是对社区居住的老年人的研究（男性占46.0％，年龄66.5 +/- 10.1岁）。评估了与CRP相关的社会心理（社会地位，婚姻状况，抑郁症状），行为（吸烟，体育锻炼，酒精）和心血管危险因素（血压，胆固醇，糖化血红蛋白，体重指数，腰围）。结果：在7.5％的样品中记录到非常高的CRP浓度。在调整了年龄，性别，急性感染和慢性炎症后，很高的CRP与较低的社会地位，抑郁症状，缺乏运动，吸烟和戒酒有关。 CRP类别中心血管危险因素的流行呈线性趋势，分别为低（<1mg / L），中（1至<3mg / L），高（3-10mg / L）和非常高（> 10mg / L） L），尽管观察到高和极高组之间的风险差异很小。结论：老年参与者中很高的CRP水平可能反映了慢性健康和心理社会逆境，而与急性感染无关。

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