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首页> 外文期刊>Atherosclerosis >High-resolution radial artery intima-media thickness and cardiovascular risk factors in patients with suspected coronary artery disease - Comparison with common carotid artery intima-media thickness
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High-resolution radial artery intima-media thickness and cardiovascular risk factors in patients with suspected coronary artery disease - Comparison with common carotid artery intima-media thickness

机译:疑似冠心病患者的高分辨率radial动脉内膜中层厚度和心血管危险因素-与颈总动脉内膜中层厚度的比较

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Objective: The radial artery wall structure can be measured with non-invasive very high-resolution ultrasound with great feasibility and high accuracy. In the present study, we aim to explore clinical correlates of radial artery intima-media thickness (rIMT), in a relatively large patient cohort with suspected coronary artery disease, and further compare those to common carotid artery IMT (cIMT) that is an accepted surrogate marker of atherosclerosis. Methods: Four hundred and sixteen patients referred to myocardial perfusion scintigram (MPS) were recruited, and cIMT and rIMT were scanned using conventional and very high-resolution ultrasound (55. MHz transducer), respectively. A number of plasma biomarkers were also measured. Results: Both cIMT and rIMT were similarly correlated with disease history, MPS-verified ischemia, carotid plaque burden, and lipid status. Repeated measurement of rIMT showed acceptable variability. Conclusion: Radial artery IMT may constitute a novel feasible imaging biomarker for systemic atherosclerosis burden, which may be used in future imaging trials to evaluate, e.g. anti-atherosclerotic treatments.
机译:目的:利用非侵入性超高分辨率超声测量The动脉壁结构具有很大的可行性和准确性。在本研究中,我们旨在探讨相对较大的可疑冠状动脉疾病患者队列中radial动脉内膜中层厚度(rIMT)的临床相关性,并将其与公认的颈总动脉IMT(cIMT)进行比较。动脉粥样硬化的替代标志物。方法:招募了116例心肌灌注显像(MPS)患者,分别使用常规和超高分辨率超声(55. MHz换能器)对cIMT和rIMT进行扫描。还测量了许多血浆生物标志物。结果:cIMT和rIMT与疾病史,经MPS验证的局部缺血,颈动脉斑块负担和血脂状况相似。重复测量rIMT显示可接受的变异性。结论:Rad动脉IMT可能构成一种新的可行的系统性动脉粥样硬化负担的影像学生物标志物,可在将来的影像学试验中用于评估例如抗动脉粥样硬化治疗。

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