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Differential effects of daily-moderate versus weekend-binge alcohol consumption on atherosclerotic plaque development in mice

机译：每日适量饮酒与周末适量饮酒对小鼠动脉粥样硬化斑块形成的差异影响

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Objectives: We examined the effect of daily-moderate (2 drinks/day, 7 days/week) and weekend-binge (7 drinks/day, 2 days/week) patterns of alcohol consumption on plasma lipid levels and physiological parameters of atherosclerotic plaque development. Methods: ApoE k/o mouse were fed (1) 'daily-moderate' (blood alcohol content: 0.07%) or (2) 'weekend-binge' (blood alcohol content: 0.23%), or (3) an isocaloric cornstarch mix. Then, to induce atherosclerotic plaque formation, all groups underwent partial carotid artery ligation, started on an atherogenic diet and continued on the alcohol feeding regimen. After 2 weeks plasma lipid levels and atherosclerotic plaque formation were assessed. Results: While there was an increase in HDL-C levels in both binge and moderate groups, LDL-C levels were significantly decreased in the daily-moderate drinking mice and significantly elevated in the weekend-binge drinking mice. In the daily-moderate alcohol group there was a decrease in atherosclerotic plaque volume, concomitant with an increase in lumen volume and decreased macrophage accumulation, when compared to no alcohol mice. In contrast, after 4 weeks of weekend-binge alcohol there was an increase in plaque volume, concomitant with a decrease in lumen volume and increased deposition of macrophages. Conclusion: These findings demonstrate for the first time a differential effect of daily-moderate vs. weekend-binge alcohol consumption on atherosclerotic plaque development and highlight the importance of patterns of alcohol consumption, as opposed to total amount consumed, in relation to the cardiovascular effects of alcohol.
机译：目的：我们研究了每日中度饮酒（每天2杯，每天7天，每周）和周末暴饮暴食（每天7杯，每天2天，每周）饮酒模式对血浆脂质水平和动脉粥样硬化斑块生理参数的影响发展。方法：给ApoE k / o小鼠喂食（1）“每日中度”（血液酒精含量：0.07％）或（2）“周末暴饮暴食”（血液酒精含量：0.23％），或（3）等热量玉米淀粉混合。然后，为了诱导动脉粥样硬化斑块的形成，所有组均进行部分颈动脉结扎，开始采用致动脉粥样化饮食，并继续采用酒精喂养方案。 2周后评估血浆脂质水平和动脉粥样硬化斑块形成。结果：尽管狂饮和中度组的HDL-C水平均升高，但日中饮酒小鼠的LDL-C水平显着降低，周末饮酒小鼠的LDL-C水平显着升高。与无酒精小鼠相比，在每日中度酒精组中，动脉粥样硬化斑块体积减少，同时腔体积增加和巨噬细胞积累减少。相反，周末饮酒4周后，斑块体积增加，同时管腔体积减少，巨噬细胞沉积增加。结论：这些发现首次证明了每日中度饮酒与周末略微饮酒对动脉粥样硬化斑块形成的不同影响，并强调了相对于总消费量而言，饮酒方式对心血管影响的重要性酒

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