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首页> 外文期刊>Annales de biologie clinique >Placental growth factor (PlGF) and sFlt-1 during pregnancy: physiology, assay and interest in preeclampsia
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Placental growth factor (PlGF) and sFlt-1 during pregnancy: physiology, assay and interest in preeclampsia

机译：妊娠期间胎盘生长因子（PlGF）和sFlt-1：子痫前期的生理学，检测方法和兴趣

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摘要

The placental growth factor (PlGF) and its soluble receptor (sFlt-1) are circulating angiogenic factors. During pregnancy these factors are released by the placenta into the maternal circulation. Preeclampsia affects 2-7% of pregnant women according to their risk factors and is characterized by high blood pressure and the onset of de novo proteinuria in the second half of pregnancy. Alterations of the sFlt-1/PlGF ratio in preeclampsia correlate with the diagnosis and adverse outcomes, particularly when the disease presents prematurely (<34 weeks). These factors can be assayed in maternal blood and measuring the sFlt-1/PlGF ratio is now available. We propose in this work to update the knowledge of these two molecules, describe their roles and evolution during normal pregnancy and preeclampsia, and finally to focus on the available assays.
机译：胎盘生长因子（PlGF）及其可溶性受体（sFlt-1）是循环性血管生成因子。在怀孕期间，这些因素通过胎盘释放到母体循环中。子痫前期根据其危险因素影响2-7％的孕妇，其特征是高血压和妊娠后半期从头蛋白尿发作。子痫前期sFlt-1 / PlGF比值的变化与诊断和不良后果相关，特别是当疾病过早出现（<34周）时。可以在母体血液中分析这些因素，现在可以测量sFlt-1 / PlGF比率。我们在这项工作中建议更新这两个分子的知识，描述它们在正常妊娠和先兆子痫期间的作用和演变，最后将重点放在可用的测定上。

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