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首页> 外文期刊>Australasian journal of ecotoxicology: the official journal of the Australasian Society for Ecotoxicology >EFFECT OF THE PESTICIDE CARBARYL ON THE PRODUCTION OF THE SKIN PEPTIDES OF LITORIA RANIFORMIS FROGS
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EFFECT OF THE PESTICIDE CARBARYL ON THE PRODUCTION OF THE SKIN PEPTIDES OF LITORIA RANIFORMIS FROGS

机译：杀虫剂甲萘啶对山毛榉皮多肽生产的影响

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Environmental pollutants and microbial pathogens may have synergistic interactions in population declines of frogs and other amphibians. Sub-lethal levels of pollutants can suppress immune defences and thereby increase susceptibility to disease. An important innate immune defence of frog skin against invading pathogens is the secretion of antimicrobial peptides from specialised granular glands. The carbamate pesticide carbaryl was assessed for its ability to affect production and antimicrobial activity of skin peptides of Litoria raniformis frogs against the opportunistic bacterial pathogen, Klebsiella pneumoniae. Animals were exposed to carbaryl (0.48 mg L~(-1)), K. pneumoniae (2 x 10~7 colony forming units mL~(-1)), a combination of both or pond water only (controls) for 16 h. Natural peptide mixtures were collected after exposure to all of these treatments and tested for activity against K. pneumoniae. Morbidity or mortality was not observed in any of the treated or control animals. No significant differences in the effectiveness of peptide mixtures against K. pneumoniae were observed among treated or control animals which may explain lack of morbidity and mortality. The total amount of recovered peptides from animals exposed to K. pneumoniae was significantly greater than in control animals indicating that skin peptides may be inducible. In contrast, the total amount of recovered peptides from animals exposed to carbaryl and carbaryl and K. pneumoniae was significantly less than in control animals. Carbaryl appears to reduce the amount of bio-active peptides produced by L. raniformis and potentially could increase susceptibility to disease of animals during exposure in the field.
机译：环境污染物和微生物病原体可能在青蛙和其他两栖动物种群减少中具有协同作用。污染物的致死水平可以抑制免疫防御，从而增加对疾病的敏感性。青蛙皮肤针对入侵病原体的重要先天免疫防御是特殊颗粒状腺体分泌的抗菌肽。评估了氨基甲酸酯杀虫剂西维因对甲虫蛙蛙皮肤肽对机会性细菌性病原体肺炎克雷伯菌的影响和抗菌活性。将动物暴露于西维因（0.48 mg L〜（-1）），肺炎克雷伯菌（2 x 10〜7个菌落形成单位mL〜（-1）），两者或仅与池塘水混合使用（对照）16小时。暴露于所有这些处理后，收集天然肽混合物，并测试其抗肺炎克雷伯菌的活性。在任何治疗或对照动物中均未观察到发病率或死亡率。在治疗或对照动物中，未观察到肽混合物对肺炎克雷伯菌的有效性有显着差异，这可以解释为缺乏发病率和死亡率。从暴露于肺炎克雷伯菌的动物中回收的肽的总量明显大于对照动物，表明皮肤肽可能是可诱导的。相反，从暴露于西芳基和西芳基和肺炎克雷伯菌的动物中回收的肽总量明显少于对照动物。甲萘威似乎减少了由兰状乳杆菌产生的生物活性肽的数量，并有可能增加田间暴露期间对动物疾病的敏感性。

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