...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medicinal Chemistry >Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (N-Heterocyclic Carbene)-Amine-Pt(II) Complexes
【24h】

Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (N-Heterocyclic Carbene)-Amine-Pt(II) Complexes

机译：Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (N-Heterocyclic Carbene)-Amine-Pt(II) Complexes

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Bioactive NHC-transition metal complexes have shown promiseasanti-cancer agents, but their potential use as radiosensitizers hasbeen neglected so far. We disclose here a new series of bimetallicplatinum-(II) complexes displaying NHC-type bridging ligands, (bis-NHC)-[trans-Pt-(RNH2)-I-2](2), thathave been synthesized via a simple, two-step procedure. They displaycytotoxicity in the micromolar range on cancerous cell lines, accumulatein cells, and bind to genomic DNA, by inducing DNA damages. Notably,these bimetallic complexes demonstrate significant radiosensitizingeffects on both ovarian cells A2780 and nonsmall lung carcinoma cellsH1299. Further investigations revealed that bimetallic species makeirradiation-induced DNA damages more persistent by inhibiting repairmechanisms. Indeed, a higher and persistent accumulation of both & gamma;-H2AXand 53BP1 foci post-irradiation was detected, in the presence of theNHC-Pt complexes. Overall, we provide the first in vitro evidencefor the radiosensitizing properties of NHC-platinum complexes, whichsuggests their potential use in combined chemo-radio therapy protocols.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号