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首页> 外文期刊>Brain injury: BI >Moderate-severe traumatic brain injury causes delayed loss of white matter integrity: Evidence of fornix deterioration in the chronic stage of injury
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Moderate-severe traumatic brain injury causes delayed loss of white matter integrity: Evidence of fornix deterioration in the chronic stage of injury

机译：中度重度创伤性脑损伤导致白质完整性延迟丧失：在慢性损伤阶段穹for变坏的证据

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Objectives: To examine structural integrity loss in the fornix from 5-30 months after moderate and severe traumatic brain injury (TBI) using diffusion tensor imaging. Methods: MRIs were prospectively undertaken in 29 adults with moderate and severe TBI at two time points. Fractional anisotropy (FA) was calculated for the fornix (column/body, right crux and left crux) at 5 and 30 months post-injury. Results: Paired t-tests revealed significant FA reductions with large effect sizes across time in the column/body, p<0.001, right crux, p<0.001 and left crux, p<0.001. Conclusions: These data contribute to the growing body of evidence that loss of white matter continues in moderate and severe TBI even after the acute neurological effects of TBI have resolved. As the fornix plays a critical role in memory, this may be a contributing factor to the poor clinical outcomes observed in these patients.
机译：目的：使用扩散张量成像技术检查中度和重度颅脑损伤（TBI）后5-30个月后穹ni的结构完整性丧失。方法：前瞻性地在两个时间点对29名中度和重度TBI成人进行了MRI检查。在受伤后5个月和30个月，计算穹ni的分数各向异性（FA）（柱/身，右足和左足）。结果：配对t检验显示，随着时间的推移，色谱柱/体内的FA显着降低，且效应大小较大，p <0.001，右关键点，p <0.001，左关键点，p <0.001。结论：这些数据为越来越多的证据表明，即使在TBI的急性神经系统作用消失后，中度和重度TBI中白质的损失仍在继续。由于穹ni在记忆中起关键作用，这可能是导致这些患者临床效果差的一个因素。

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