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首页> 外文期刊>Brain: A journal of neurology >Can physical exercise in old age improve memory and hippocampal function?
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Can physical exercise in old age improve memory and hippocampal function?

机译：老年体育锻炼可以改善记忆力和海马功能吗？

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Physical activity can offer protection against cognitive decline and neurodegenerative diseases, but whether it slows the trajectory of normal ageing or boosts plasticity above and beyond preservation of function is unclear. Duzel et al. examine the evidence that exercise improves hippocampal plasticity in ageing and discuss avenues for future research.Physical activity can offer protection against cognitive decline and neurodegenerative diseases, but whether it slows the trajectory of normal ageing or boosts plasticity above and beyond preservation of function is unclear. Duzel et al. examine the evidence that exercise improves hippocampal plasticity in ageing and discuss avenues for future research.Physical exercise can convey a protective effect against cognitive decline in ageing and Alzheimer's disease. While the long-term health-promoting and protective effects of exercise are encouraging, it's potential to induce neuronal and vascular plasticity in the ageing brain is still poorly understood. It remains unclear whether exercise slows the trajectory of normal ageing by modifying vascular and metabolic risk factors and/or consistently boosts brain function by inducing structural and neurochemical changes in the hippocampus and related medial temporal lobe circuitry-brain areas that are important for learning and memory. Hence, it remains to be established to what extent exercise interventions in old age can improve brain plasticity above and beyond preservation of function. Existing data suggest that exercise trials aiming for improvement and preservation may require different outcome measures and that the balance between the two may depend on exercise intensity and duration, the presence of preclinical Alzheimer's disease pathology, vascular and metabolic risk factors and genetic variability.
机译：体力活动可以提供抵抗认知能力下降和神经退行性疾病的保护作用，但是尚不清楚它是否能减缓正常衰老的轨迹或增强功能性之外的可塑性。 Duzel等。研究运动可以改善衰老过程中海马可塑性的证据，并讨论未来的研究途径。体育活动可以为认知能力下降和神经退行性疾病提供保护，但尚不清楚它是否能减缓正常衰老的轨迹或增强其在保持功能之外的可塑性。 Duzel等。研究运动可以改善衰老过程中海马可塑性的证据，并讨论未来的研究途径。体育锻炼可以预防衰老和阿尔茨海默氏病的认知能力下降。尽管长期的运动促进健康和保护作用令人鼓舞，但对于衰老的大脑诱发神经元和血管可塑性的潜力仍知之甚少。尚不清楚运动是否通过改变血管和代谢危险因素来减缓正常衰老的轨迹和/或通过诱导海马和相关的颞叶内侧脑回路的结构和神经化学变化来持续增强大脑功能，这对于学习和记忆很重要。因此，尚需确定老年运动干预能在多大程度上改善大脑的可塑性，而不能维持其功能。现有数据表明，旨在改善和保存的运动试验可能需要不同的结果指标，两者之间的平衡可能取决于运动强度和持续时间，临床前阿尔茨海默氏病的病理，血管和代谢危险因素以及遗传变异性。

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