In nasal septal deviation, the deviated narrow side is more frequently combined with sinusitis due to the mechanical obstruction of ostiomeatal unit. The purpose of this study was to determine whether reduced airflow has a harmful effect on nasal inflammation and the development of rhinosinusitis. Twenty-three healthy New Zealand white rabbit were used. One side of the nostril was closed in 15 rabbits and 5 rabbits served as control. Rabbits were sacrificed at 4, 8 and 12 weeks. The anterior maxillary and septal mucosa were obtained for EM and LM study. Mucociliary clearance rate was measured using the India ink method. At 4 weeks, the opened side mucosa showed ciliary losses and ulcerations in the mucosa, but at 8 and 12 weeks, the closed side showed more severe ulceration and ciliary loss than open side. The mucociliary clearance rate was 12.3 mm/min in the control group, but the open side was 8.7 and 7.1 mm/min and the closed side was 4.7 and 6.4 mm/min at 4 and 8 weeks, respectively. Electron microscopy showed many abnormal cilia at 8 weeks in both sides. These observations suggest that inadequate airflow is an important causative factor of nasal and sinus infection, and that patients with septal deviation have a similar chance of developing sinusitis in either side.
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机译：在鼻中隔偏斜中，由于眼睑单元的机械阻塞，偏斜的狭窄侧更常合并鼻窦炎。这项研究的目的是确定气流减少是否对鼻炎症和鼻-鼻窦炎的发展产生有害影响。使用了二十三只健康的新西兰白兔。在15只兔子中封闭鼻孔的一侧，将5只兔子用作对照。在第4、8和12周处死兔子。获得上颌前和隔膜黏膜用于EM和LM研究。粘膜纤毛清除率使用印度墨水法测量。在第4周，开放侧粘膜显示出粘膜的睫状体损失和溃疡，但是在第8和12周时，封闭侧显示出比开放侧更严重的溃疡和睫状体损失。对照组的粘膜纤毛清除率分别为12.3 mm / min，但在第4周和第8周，开放侧分别为8.7 mm / min和7.1 mm / min，封闭侧为4.7 mm / min和6.4 mm / min。电镜显示在8周时，两侧都有许多异常纤毛。这些观察结果表明，气流不足是鼻和鼻窦感染的重要病因，并且存在间隔偏斜的患者在任一侧发生鼻窦炎的机会均相似。
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