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首页> 外文期刊>Auris, nasus, larynx >Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment.
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Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment.

机译：补锌对味觉障碍患者血清锌浓度和血管紧张素转化酶载脂蛋白/全息活性比率的影响。

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OBJECTIVE: The aim of the present study was to evaluate the effects of zinc supplementation on hypogeusia, serum zinc concentration and the ratio of apo/holo-activities of angiotensin converting enzyme (ACE ratio) in patients with taste impairment. ACE ratio was used as an index of zinc nutritional status. METHODS: Forty patients complaining of taste impairment were divided into two groups: zinc deficiency taste impairment (n=12) and idiopathic taste impairment (n=28). Patients with zincemia values of less than 63 microg/dl with no history of other disorder or medication known to cause dysgeusia were diagnosed as zinc deficiency group, while those with the same condition and values more than 64 microg/dl were considered to belong to the idiopathic group. Patients orally received 150 mg of polaprezinc containing 33 mg of zinc every day. Subjective symptom was scored according to visual analogue scale (VAS). RESULTS: Zinc supplementation improved hypogeusia in both idiopathic and zinc deficiency groups. The mean improvements of VAS were 3.02+/-3.03 in the idiopathic group and 3.13+/-2.53 in the zinc deficiency group. Thus, there were no significant differences in idiopathic and zinc deficiency groups. Significant correlations were found between the improvement of VAS score and the ACE ratio after zinc supplementation in both idiopathic and zinc deficiency groups. On the contrary, significant correlations were not found between the improvement of VAS score and the zinc concentration in the serum after zinc supplementation in both groups. CONCLUSION: The results of the present study indicated that zinc deficiency is a predominant factor underlying taste impairment and ACE ratio may be a predictor of the prognosis for taste impairment after zinc supplementation, in addition to a more sensitive indicator of zinc nutrition than zinc concentration in the serum.
机译：目的：本研究的目的是评估补充锌对味觉障碍患者的体力减退，血清锌浓度以及血管紧张素转化酶的载脂蛋白/全酶活性比率（ACE比）的影响。 ACE比用作锌营养状况的指标。方法：将40名抱怨味觉障碍的患者分为两组：锌缺乏味觉障碍（n = 12）和特发性味觉障碍（n = 28）。锌血症值小于63 microg / dl的患者，无其他疾病史或已知引起消化不良的药物史，被诊断为锌缺乏症组，而病情相同且值大于64 microg / dl的患者被认为属于锌缺乏症组。特发性群体。患者每天口服150毫克含锌33毫克的Polaprezinc。根据视觉模拟量表（VAS）对主观症状进行评分。结果：补充锌可改善特发性和锌缺乏症组的体力减退。特发性组VAS的平均改善为3.02 +/- 3.03，而锌缺乏组VAS的平均改善为3.13 +/- 2.53。因此，特发性和缺锌组之间没有显着差异。在特发性和缺锌组中，补锌后VAS评分的改善与ACE比率之间存在显着相关性。相反，在两组中补充锌后，VAS评分的改善与血清中锌浓度之间没有发现显着的相关性。结论：本研究结果表明，锌缺乏是引起味觉障碍的主要因素，ACE比率可能是补充锌后味觉障碍预后的预测指标，此外锌营养比锌浓度更敏感。血清。

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