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首页> 外文期刊>Auris, nasus, larynx >Brain activity related to phonation in young patients with adductor spasmodic dysphonia
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Brain activity related to phonation in young patients with adductor spasmodic dysphonia

机译：内收性痉挛性肌张力障碍年轻患者中与发声有关的大脑活动

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Objective: This study investigated the brain activities during phonation of young patients with adductor spasmodic dysphonia (ADSD) of relatively short disease duration (<10 years). Methods: Six subjects with ADSD of short duration (mean age: 24. 3 years; mean disease duration: 41 months) and six healthy controls (mean age: 30.8 years) underwent functional magnetic resonance imaging (fMRI) using a sparse sampling method to identify brain activity during vowel phonation (/i:/). Intragroup and intergroup analyses were performed using statistical parametric mapping software. Results: Areas of activation in the ADSD and control groups were similar to those reported previously for vowel phonation. All of the activated areas were observed bilaterally and symmetrically. Intergroup analysis revealed higher brain activities in the SD group in the auditory-related areas (Brodmann's areas [BA] 40, 41), motor speech areas (BA44, 45), bilateral insula (BA13), bilateral cerebellum, and middle frontal gyrus (BA46). Areas with lower activation were in the left primary sensory area (BA1-3) and bilateral subcortical nucleus (putamen and globus pallidus). Conclusion: The auditory cortical responses observed may reflect that young ADSD patients control their voice by use of the motor speech area, insula, inferior parietal cortex, and cerebellum. Neural activity in the primary sensory area and basal ganglia may affect the voice symptoms of young ADSD patients with short disease duration.
机译：目的：本研究调查了疾病持续时间相对较短（<10年）的年轻内收性痉挛性肌张力障碍（ADSD）患者发声时的大脑活动。方法：对六名短时ADSD（平均年龄：24。3岁;平均病程：41个月）的受试者和六名健康对照（平均年龄：30.8岁）进行了稀疏采样法的功能性磁共振成像（fMRI），识别元音发声（/ i：/）期间的大脑活动。使用统计参数映射软件进行组内和组间分析。结果：ADSD和对照组的激活区域与先前报道的元音发声区域相似。从侧面和侧面观察所有激活区域。小组间分析显示，SD组在听觉相关区域（Brodmann's区域[BA] 40、41），运动言语区域（BA44、45），双侧小岛（BA13），双侧小脑和额中回中有较高的大脑活动（ BA46）。激活程度较低的区域位于左侧的主要感觉区域（BA1-3）和双侧皮质下核（丘脑和苍白球）。结论：观察到的听觉皮质反应可能反映出年轻的ADSD患者通过运动言语区，绝缘体，顶叶下皮质和小脑来控制自己的声音。初级感官区域和基底神经节的神经活动可能会影响病程短的年轻ADSD患者的声音症状。

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