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首页> 外文期刊>Auris, nasus, larynx >Topical Nigella sativa for nasal symptoms in elderly
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Topical Nigella sativa for nasal symptoms in elderly

机译：局部使用Nigella sativa治疗老年人的鼻症状

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摘要

Objective: To compare the effects of intranasal application of black seed (Nigella Sativa) oil (NSO) and isotonic sodium chloride solution (ISCS) on nasal symptoms of the elderly. Methods: In this prospective, crossover randomized controlled trial, 42 geriatric patients with nasal dryness and related symptoms were randomized to receive either 2 weeks of isotonic sodium chloride solution (ISCS) followed by 2 weeks of N. sativa oil (NG oil) or the same treatment in the opposite order. There was a washout period of 3 weeks in between the treatment periods. Subjective symptoms including nasal dryness, burning, obstruction, itching and crusting were evaluated by a visual analog scale. Mucociliary function was evaluated with saccharin test. Results: Nasal dryness, obstruction and crusting improved significantly with the use of NSO compared to ISCS without any evidence of relevant carryover effects (p < 0.05 for all for the difference in treatment). There was no significant difference between the effect of NSO and ISCS on nasal burning and itching (p > 0.05 for all). There was no change in mucociliary clearance during any of the treatment periods. Conclusion: NSO is a better alternative to ISCS to treat nasal mucosa symptoms due to aging.
机译：目的：比较鼻内施用黑籽（Nigella Sativa）油（NSO）和等渗氯化钠溶液（ISCS）对老年人鼻部症状的影响。方法：在这项前瞻性，交叉的随机对照试验中，将42例鼻干燥和相关症状的老年患者随机分为两组，分别接受2周的等渗氯化钠溶液（ISCS）和2周的紫花苜蓿油（NG oil）或以相反的顺序进行相同的处理。在两个治疗期之间有3周的清除期。通过视觉模拟量表评估主观症状，包括鼻干燥，烧灼，阻塞，瘙痒和结cru。用糖精试验评估粘膜纤毛功能。结果：与ISCS相比，使用NSO可使鼻干，阻塞和结s明显改善，而没有任何相关残留效应的证据（对于所有治疗差异，p <0.05）。 NSO和ISCS对鼻烧伤和瘙痒的作用之间无显着差异（所有p> 0.05）。在任何治疗期间，粘膜纤毛清除率均无变化。结论：NSO是ISCS更好的替代品，可用于治疗因衰老而引起的鼻粘膜症状。

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