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首页> 外文期刊>Auris, nasus, larynx >Effect of prehydration on nasal mucociliary clearance in low relative humidity.
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Effect of prehydration on nasal mucociliary clearance in low relative humidity.

机译：在低相对湿度下预水合对鼻粘膜纤毛清除的影响。

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OBJECTIVE: Nasal mucociliary clearance, which plays an important role in defending the respiratory system, tends to decrease under conditions of low relative humidity (RH). The purpose of this randomized cross-over study was to investigate the preventive effect of prehydration on nasal mucociliary clearance under low RH conditions. METHODS: Fourteen young healthy subjects were assigned to three interventions: prehydration (6ml/kg body weight) using water (W), prehydration using a carbohydrate-electrolyte beverage (CE), and control conditions (Cont) with no prehydration. For each intervention trial, subjects sat for 4h in an environmental chamber (23 degrees C, 10% RH). Nasal mucociliary clearance was measured by the saccharin transit time (ST). Furthermore, a dry sensation of the mucosa, urine volume, and body weight were measured at the baseline, 2h and 4h after entering the environmental chamber, respectively. RESULTS: ST was prolonged under the Cont conditions after entering the environmental chamber. Prehydration with CE led to a significantly lower ST compared to the Cont pretreatment at 2h, whereas the W trial showed no significance difference in comparison to the Cont values. CONCLUSION: These results suggest that prehydration with a carbohydrate-electrolyte beverage is therefore beneficial for maintaining better nasal mucociliary clearance at least for 2h under low RH conditions.
机译：目的：鼻粘膜纤毛清除在保护呼吸系统中起重要作用，在相对湿度（RH）较低的情况下往往会降低。这项随机交叉研究的目的是研究低湿度条件下预水合对鼻粘膜纤毛清除的预防作用。方法：将十四名年轻健康受试者分为三类干预措施：使用水（W）进行预水合（6ml / kg体重），使用碳水化合物电解质饮料（CE）进行预水合以及不进行预水合的对照条件（Cont）。对于每个干预试验，受试者在一个环境室内（23摄氏度，相对湿度10％）坐4小时。鼻粘膜纤毛清除率通过糖精转运时间（ST）测量。此外，分别在进入环境室后2小时和4小时的基线测量粘膜的干燥感，尿量和体重。结果：ST在进入环境箱后在Cont条件下被延长。与2小时的Cont预处理相比，使用CE预先水合导致的ST显着降低，而W试验与Cont值相比没有显着差异。结论：这些结果表明，在低RH条件下，用碳水化合物电解质饮料进行预水化有利于维持更好的鼻粘膜纤毛清除率至少2小时。

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