...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Auris, nasus, larynx >Difference of pharyngeal morphology and mechanical property between OSAHS patients and normal subjects.
【24h】

Difference of pharyngeal morphology and mechanical property between OSAHS patients and normal subjects.

机译：OSAHS患者和正常人之间的咽部形态和力学性能的差异。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The intrinsic properties such as baseline caliber and compliance of upper airway are thought to be important in the pathogenesis of obstructive sleep apnea hypopnea syndrome (OSAHS). Our study was designed to detect the difference of baseline caliber (morphological property) of pharynx during both wakefulness and sleep, and difference of pharyngeal compliance (mechanical property) between OSAHS patients and normal subjects. METHODS: CT scan was performed on 7 normal subjects and 13 OSAHS patients when they are awake, during drug-induced sleep with minimally effective therapeutic pressure (P(eff)), 0 cmH2O, and critical pressure (P(crit)) being given via a nose mask system, respectively. 3D images of pharyngeal airway were reconstructed, and volume of each subdivision of pharynx was measured. Volume, average area and compliance of each subdivision and in total were compared between the two groups. RESULTS: The OSAHS group was shown to have a smaller average area at upper (1.20+/-0.26 cm2 versus 1.57+/-0.17 cm2, p<0.05) and middle part of pharynx (1.89+/-0.52 cm2 versus 2.58+/-0.27 cm2, p<0.05) during wakefulness. During sleep, this difference was shown to be even more obvious at upper part (0.77+/-0.30 cm2 versus 1.45+/-0.18 cm2, p<0.01); and middle part, (1.15+/-0.47 cm2 versus 2.44+/-0.26 cm2, p<0.01). The average area during wakefulness and sleep was also shown to be highly correlated. OSAHS group had a higher compliance at middle part (0.28+/-0.15 cmH2O(-1) versus 0.13+/-0.07 cmH2O(-1), p<0.05) of pharynx. CONCLUSION: We conclude that OSAHS patients have a narrower and more collapsible upper airway than normal subjects do, the caliber data obtained during wakefulness could reflect the baseline caliber during sleep, and our method is valid to evaluate both morphology and function of upper airway.
机译：目的：内在特性如基线口径和上呼吸道顺应性在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的发病机制中很重要。我们的研究旨在检测清醒和睡眠期间咽部的基线口径（形态学特性）的差异，以及OSAHS患者和正常受试者之间的咽部顺应性（机械特性）的差异。方法：在药物诱导的睡眠期间，对7名正常受试者和13名OSAHS患者清醒时进行CT扫描，并给予最低有效治疗压力（P（eff）），0 cmH2O和临界压力（P（crit））分别通过鼻罩系统。重建咽部气道的3D图像，并测量咽部每个细分的体积。比较两组之间每个分区的体积，平均面积和顺应性。结果：OSAHS组的上半部平均面积较小（1.20 +/- 0.26 cm2对1.57 +/- 0.17 cm2，p <0.05）和咽中部（1.89 +/- 0.52 cm2对2.58 + / -0.27 cm2，p <0.05）。在睡眠期间，这种差异在上部更为明显（0.77 +/- 0.30 cm2对1.45 +/- 0.18 cm2，p <0.01）;中部（1.15 +/- 0.47 cm2对2.44 +/- 0.26 cm2，p <0.01）。清醒和睡眠期间的平均面积也显示出高度相关。 OSAHS组在咽部中部的依从性更高（0.28 +/- 0.15 cmH2O（-1）相对于0.13 +/- 0.07 cmH2O（-1），p <0.05）。结论：我们得出的结论是，OSAHS患者的上呼吸道比正常人狭窄且更易折叠，清醒过程中获得的口径数据可以反映睡眠时的基线口径，我们的方法对于评估上呼吸道的形态和功能均有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号