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首页> 外文期刊>Auris, nasus, larynx >Oculomotor findings mimicking a cerebellar disorder and postural control in severe Meniere's disease.
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Oculomotor findings mimicking a cerebellar disorder and postural control in severe Meniere's disease.

机译：在严重的梅尼埃病中，动眼动能的发现可模仿小脑疾病和姿势控制。

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OBJECTIVE: We explored whether vestibular derangement in patients with severe Meniere's disease is related to gaze and fixation difficulties and could explain complains of visual blurring and visual neglect. METHODS: Twenty-six patients with severe Meniere's disease treated with intratympanically applied gentamicin of the affected ear were examined. Saccades (with pseudo-random timing, size and side of the step) and pursuit eye movements (PEMs; pseudo-random target trajectory made of a combination of two sinusoidal waves of different frequencies) and posturography were tested in patients. For normative data of voluntary eye movements, 45 control subjects were tested, and for posturography 29 control subjects. Severity of symptoms in Meniere patients was assessed according to the total handicap score of AAO-HNSF (1985). RESULTS: Saccadic eye movements and postural stability were severely deteriorated in Meniere patients, and these disturbances correlated significantly with each other. Most of PEM parameters were significantly worse in Meniere patients than in control subjects. Prolongation of saccadic latency and reduced gains due to saccadization in PEMs were characteristic features for Meniere's patients. Severity of symptoms in Meniere patients correlated with prolongation of latency in saccades and with poorer gains in PEMs. Postural instability measured with posturography correlated with saccadic latency and PEMs. CONCLUSION: In severe Meniere's disease, programming of oculomotor and postural responses show the same pattern of disturbance, an increased delay of processing and inaccuracy in the motor output. A fluctuant vestibular lesion with advanced severity can cause disorders of voluntary eye movements that are reflected with clinical complaints of difficulties in reading and visual scanning of surrounding.
机译：目的：我们探讨了严重美尼尔氏病患者的前庭脱位是否与注视和注视困难有关，并可以解释视力模糊和视力忽视的主诉。方法：对26例患有严重美尼尔氏病的患者进行了鼓室内应用庆大霉素的治疗。在患者中测试了扫视（具有伪随机的时间，大小和台阶的侧面）和追踪眼球运动（PEM;由两个不同频率的正弦波组合而成的伪随机目标轨迹）和体位图。对于自愿性眼球运动的规范性数据，测试了45位对照对象，对于姿势描记法，对29位对照对象进行了测试。根据AAO-HNSF的总残障评分（1985年）评估美尼尔患者的症状严重程度。结果：梅尼埃患者的眼球运动和姿势稳定性严重恶化，这些障碍之间存在显着相关性。美尼尔（Meniere）患者的大多数PEM参数明显比对照组的患者差。梅尼埃病患者的特征性特征是，眼球潜伏期延长和PEM眼球震荡导致的收益减少是其特征。美尼尔病患者的症状严重程度与扫视潜伏期延长和PEM获益较弱有关。用姿势描记法测得的姿势不稳与行潜伏期和PEM相关。结论：在严重的梅尼埃病中，动眼和姿势反应的程序设计显示出相同的干扰模式，增加的处理延迟和运动输出的不准确性。具有严重程度的波动性前庭病变会导致自愿性眼球运动障碍，这反映在临床上，阅读和视觉扫描周围环境困难。

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