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Evaluation of a Microbial Sensor as a Tool for Antimicrobial Activity Test of Cosmetic Preservatives

机译：微生物传感器作为化妆品防腐剂抗菌活性测试工具的评估

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摘要

For high-throughput screening of novel cosmetic preservatives, a rapid and simple assay to evaluate the antimicrobial activities should be developed because the conventional agar dilution method is time-consuming and labor-intensive. To address this issue, we evaluated a microbial sensor as a tool for rapid antimicrobial activity testing. The sensor consists of an oxygen electrode and a filter membrane that holds the test microorganisms, Staphylococcus aureus and Candida albicans. The antimicrobial activity of the tested cosmetic preservative was evaluated by measuring the current increases corresponding to the decreases in oxygen consumption in the microbial respiration. The current increases detected by the sensor showed positive correlation to the concentrations of two commercially used preservatives, chlorphenesin and 2-phenoxyethanol. The same tendency was also observed when a model cosmetic product was used as a preservative solvent, indicating the feasibility in practical use. Furthermore, the microbial sensor and microfluidic flow-cell was assembled to achieve sequential measurements. The sensor system presented in this study could be useful in large-scale screening experiments.
机译：为了高通量筛选新型化妆品防腐剂，应开发一种快速，简单的测定方法来评估其抗菌活性，因为常规的琼脂稀释方法既费时又费力。为了解决这个问题，我们评估了微生物传感器作为快速抗菌活性测试的工具。该传感器由一个氧电极和一个滤膜组成，该滤膜可容纳测试微生物，金黄色葡萄球菌和白色念珠菌。通过测量与微生物呼吸中的氧气消耗减少相对应的电流增加来评估所测试化妆品防腐剂的抗菌活性。传感器检测到的电流增加与两种商业使用的防腐剂氯酚素和2-苯氧基乙醇的浓度呈正相关。当将模型化妆品用作防腐剂溶剂时，也观察到相同的趋势，表明其在实际使用中的可行性。此外，组装了微生物传感器和微流体流通池以实现顺序测量。在这项研究中提出的传感器系统可能在大规模筛选实验中很有用。

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