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首页> 外文期刊>Autoimmunity >Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid.
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Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid.

机译：甲状腺以外的组织中甲状腺刺激激素和甲状腺刺激激素受体的生理相关性。

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摘要

Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence the outcome of T cell development in the thymus and intestine, and can affect the magnitude of antibody and cell-mediated responses of peripheral lymphocytes. Production of TSH and the expression of the TSH receptor are widely but selectively distributed across many different types of hematopoietic cells in the bone marrow, as well as among subsets of dendritic cells, monocytes and lymphocytes in the spleen and lymph nodes. In addition to their role in immunity, the involvement of TSH-producing hematopoietic cells in the microregulation of thyroid hormone activity represents a novel and potentially important aspect of the TSH-mediated immune-endocrine circuit.
机译：数十年的研究为免疫系统与下丘脑-垂体-甲状腺（HPT）轴的激素之间的相互关系提供了有力的证据。特别是，甲状腺刺激激素（TSH）已显示具有多种免疫调节性细胞因子样活性，这些活性可能会影响胸腺和肠道T细胞发育的结果，并可能影响抗体和细胞因子的强度。介导的外周淋巴细胞反应。 TSH的产生和TSH受体的表达广泛但选择性地分布在骨髓中许多不同类型的造血细胞中，以及在脾和淋巴结中的树突状细胞，单核细胞和淋巴细胞的子集中。除了它们在免疫中的作用外，产生TSH的造血细胞参与甲状腺激素活性的微调节还代表了TSH介导的免疫-内分泌回路的一个新颖且潜在的重要方面。

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