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Exon-1 polymorphism of ctla-4 gene in Iranian patients with Graves' disease.

机译：伊朗Graves病患者ctla-4基因的Exon-1多态性。

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摘要

Polymorphisms in ctla-4 gene have been shown to be associated with the Graves' disease (GD) susceptibility in different populations in the world. This study was undertaken to disclose the probable association of exon-1 polymorphism of ctla-4 with GD in Iranian patients. A49G polymorphism was investigated in 90 patients and 90 age/sex matched normal healthy controls, using PCR-SSCP and PCR-RFLP methods. Frequencies of AA, AG and GG genotypes among patients were found to be 21 (23.3%), 49 (54.5%) and 20 (22.2%) while these frequencies among healthy controls were 30 (33.3%), 53 (58.9%) and 7(7.8%), respectively. A significant increase of GG genotype and G allele was observed in patients (p = 0.012 and p = 0.025). In conclusion, consistent with the results of most other studies, the presence of a G allele in position 49 of ctla-4 exon-1 is associated with susceptibility to GD in Iranian population.
机译：ctla-4基因的多态性已被证明与世界上不同人群的Graves病（GD）易感性有关。进行了这项研究以揭示伊朗患者中ctla-4的外显子1多态性与GD的可能联系。使用PCR-SSCP和PCR-RFLP方法对90例患者和90个年龄/性别匹配的正常健康对照者进行了A49G多态性研究。患者中AA，AG和GG基因型的频率分别为21（23.3％），49（54.5％）和20（22.2％），而健康对照组中的这些频率为30（33.3％），53（58.9％）和7（7.8％）。患者中GG基因型和G等位基因显着增加（p = 0.012和p = 0.025）。总之，与大多数其他研究的结果一致，ctla-4外显子1的49位上存在G等位基因与伊朗人群中GD的易感性有关。

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