• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Autoimmunity >The role of complement in pregnancy and fetal loss.
【24h】

The role of complement in pregnancy and fetal loss.

机译：补体在妊娠和胎儿流失中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the United States, between 1 and 3% of women suffer recurrent miscarriages; 50-70% of all conceptions fail. Although in the majority of affected women the cause of recurrent miscarriages is unknown, an immune mechanism involving the inappropriate and subsequently injurious recognition of the conceptus by the mother's immune system has been proposed. Murine models have recently been developed that are relevant to this issue. We and others have identified a novel role for complement as an early effector in the pathway leading to pregnancy loss associated with placental inflammation. Indeed, it appears that inhibition of complement activation is an absolute requirement for normal pregnancy, and that in the antiphosphospholid syndrome overwhelming activation of complement triggered by antibodies (Ab) deposited in placenta leads to fetal injury. Identification of complement activation as a mediator of pregnancy loss and definition of the complement components necessary to trigger such injury is likely tolead to a better understanding of its pathogenesis and to new and improved treatments.
机译：在美国，有1-3％的妇女反复流产;所有概念中有50-70％失败。尽管在大多数受影响的妇女中，反复流产的原因尚不清楚，但已经提出了一种免疫机制，其中涉及母亲的免疫系统不适当地地并且随后有害地识别了概念。最近开发了与该问题有关的鼠模型。我们和其他人已经确定补体在导致与胎盘发炎有关的妊娠损失的途径中作为早期效应者的新作用。的确，抑制补体激活似乎是正常妊娠的绝对必要条件，而在抗磷脂综合征中，由沉积在胎盘中的抗体（Ab）触发的补体激活势不可挡会导致胎儿受伤。补体激活作为妊娠流失的介质的鉴定以及引发此类损伤所必需的补体成分的定义可能会导致人们更好地了解其发病机理并寻求新的和改进的治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号