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首页> 外文期刊>Autoimmunity >IgG antibodies to human cytomegalovirus late protein UL94 in patients with systemic sclerosis.
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IgG antibodies to human cytomegalovirus late protein UL94 in patients with systemic sclerosis.

机译：系统性硬化症患者中人巨细胞病毒晚期蛋白UL94的IgG抗体。

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Human cytomegalovirus (HCMV) has been proposed as an amplifying agent for at least some of the spectrum of systemic sclerosis (SSc; scleroderma). In support of this hypothesis, antibodies to the HCMV late protein UL94 have been detected in the majority of SSc patients in a study involving Caucasian subjects from Italy. The aim of this investigation was to determine whether elevated levels of anti-UL94 antibodies are present in African American and Caucasian SSc patients from the U.S. We further wished to determine whether there was a significant difference in the levels of anti-UL94 antibodies between the diffuse and the limited forms of the disease. IgG antibodies to a UL94 peptide were measured in 254 Caucasian and 90 African American subjects by an enzyme-linked immunosorbent assay (ELISA). In both Caucasian and African American subjects, the mean antibody level in the diffuse form of SSc was significantly higher than that in the respective control subjects (714 vs. 466 ng/ml, p = 0.005; 1226 vs. 512 ng/ml, p < 0.0001). Also, among Caucasian SSc patients, the mean antibody level in the diffuse form of SSc was significantly higher than that in the limited form of the disease (714 vs. 465 ng/ml, p = 0.02). These results show that increased levels of antibodies to the HCMV late protein UL94 are associated with SSc and they may be a marker for the severity of the disease.
机译：已经提出人巨细胞病毒（HCMV）作为系统性硬化症（SSc;硬皮病）的至少某些光谱的放大剂。为支持这一假设，在一项涉及意大利高加索受试者的研究中，大多数SSc患者中已检测到HCMV晚期蛋白UL94的抗体。这项研究的目的是确定来自美国的非洲裔美国人和高加索SSc患者中抗UL94抗体的水平是否存在升高。我们进一步希望确定弥漫性之间的抗UL94抗体水平是否存在显着差异和有限的疾病形式。通过酶联免疫吸附测定（ELISA）在254名白种人和90名非裔美国人受试者中测量了针对UL94肽的IgG抗体。在高加索人和非裔美国人受试者中，SSc弥散形式的平均抗体水平显着高于相应的对照受试者（714 vs. 466 ng / ml，p = 0.005; 1226 vs. 512 ng / ml，p <0.0001）。同样，在白种人SSc患者中，SSc弥散形式的平均抗体水平显着高于疾病有限形式的平均抗体水平（714 vs. 465 ng / ml，p = 0.02）。这些结果表明，针对HCMV晚期蛋白UL94的抗体水平升高与SSc有关，它们可能是疾病严重程度的标志。

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