CTLA-4 (CD152) and its involvement in autoimmune disease.

Holmberg D; Cilio CM; Lundholm M; Motta V

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CTLA-4 (CD152) and its involvement in autoimmune disease.

机译：CTLA-4（CD152）及其与自身免疫性疾病的关系。

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Autoimmune diseases (AID) are inherited as complex genetic diseases. Different Autoimmune diseases have been found to cluster in families and are believed to share some common etiological factors. With the exception of major histocompatibility complex (MHC) genes contributing susceptibility to these diseases have been difficult to identify. CD152 has emerged as one such candidate unifying several autoimmune diseases. We here review the evidence that CD152 constitutes a general susceptibility factor for multiple autoimmune diseases and discuss how CD152 and other co-stimulatory pathways may contribute to autoimmune pathogenesis.

机译：自身免疫性疾病（AID）作为复杂的遗传性疾病遗传。已经发现不同的自身免疫性疾病聚集在家庭中，并且被认为具有一些共同的病因。除了主要的组织相容性复合物（MHC）基因之外，这些疾病的易感性很难鉴定。 CD152已成为统一几种自身免疫性疾病的候选药物。我们在这里审查CD152构成多种自身免疫性疾病的一般易感性的证据，并讨论CD152和其他共刺激途径如何可能有助于自身免疫性发病机制。

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《Autoimmunity》 |2005年第3期|共9页
作者
Holmberg D; Cilio CM; Lundholm M; Motta V;
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正文语种 eng
中图分类基础医学;
关键词
CTLA-4; Autoimmune Diseases; Pathogenesis; Genetic; 自身免疫疾病;

机译：CTLA-4;Autoimmune Diseases;Pathogenesis;Genetic;自身免疫疾病;

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1. CTLA-4 (CD152) and its involvement in autoimmune disease. [J] . Holmberg D, Cilio CM, Lundholm M, Autoimmunity . 2005,第3期

机译：CTLA-4（CD152）及其与自身免疫性疾病的关系。
2. Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease. [J] . Ban Y, Davies TF, Greenberg DA, Genes and immunity. . 2003,第8期

机译：分析自身免疫性甲状腺疾病中的CTLA-4，CD28和诱导型共刺激物（ICOS）基因。
3. Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease. [J] . Oaks MK, Hallett KM The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第10期

机译：尖端：自身免疫性甲状腺疾病患者的可溶形式的CTLA-4。
4. Thymun: Smart Mobile Health Platform for The Autoimmune Community to Improve the Health and Well-Being of Autoimmune Sufferers in Indonesia [C] . Yasmin Salamah, Rahma Dany Asyifa, Tsonya Yumna Afifah, International Conference on Information and Communication Technology . 2020

机译：Thymun：针对自身免疫社区的智能移动健康平台，旨在改善印度尼西亚自身免疫患者的健康状况
5. AT-repeat polymorphisms of the human CTLA-4 gene: Associations with autoimmune diabetes and allele-specific variation of expression. [D] . Lowe, Robert Michael Judson. 2003

机译：人类CTLA-4基因的AT重复多态性：与自身免疫性糖尿病和等位基因特异性表达的关联。
6. Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates children and adults [O] . Aditya Arra, Maximilian Pech, Hang Fu, 2021

机译：抗原特异性人T细胞反应中的CTLA-4（CD152）的免疫检查点抑制在新生儿儿童和成人之间的症状不同
7. Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations [O] . N. Verma, S. O. Burns, L. S. K. Walker, 2017

机译：CTLA-4（CD152）突变患者的免疫缺陷和自身免疫

CTLA-4 (CD152) and its involvement in autoimmune disease.

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