Emerging roles of autophagy in the development and treatment of urothelial carcinoma of the bladder

Pratishtha Gupta; Niraj Kumar; Minal Garg

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Emerging roles of autophagy in the development and treatment of urothelial carcinoma of the bladder

机译：Emerging roles of autophagy in the development and treatment of urothelial carcinoma of the bladder

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Introduction: High recurrence rates, frequent surveillance strategies, and current multidisciplinary treatment approaches make urothelial carcinoma of bladder (UCB) one of the most expensive cancers to clinically manage. Recent studies have demonstrated a role for autophagy in bladder tumorigenesis. It serves as a tumor suppressor by maintaining genomic integrity and preventing tumor proliferation during initial stages of tumor development. Nevertheless, once established, cancer cells may utilize protective autophagy to endure cellular stress and survive in the adverse environment. Its excessive stimulation supports cancer cells' resistance to therapeutic modalities. Areas Covered: PubMed and Google Scholar electronic databases were searched for recently published studies. This review summarizes emerging roles of autophagy in development/progression of UCB and treatment resistance and explores novel therapeutic targets for prevention of cancer invasion, metastatic spread', and disease relapse. Expert Opinion: The development of novel therapies via targeting of autophagy may augment current treatment regimens and improve clinical outcomes. Synthetic compounds or plant-based metabolites are reported to enhance cancer therapies by modulating autophagic flux. Successful autophagy-focused therapeutic intervention requires a mechanistic understanding of autophagic effects on tumor initiation and progression and the development of efficient biomarkers to monitor it in tumor tissues.

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《Expert opinion on therapeutic targets》 |2021年第12期|787-797|共11页
作者
Pratishtha Gupta; Niraj Kumar; Minal Garg;
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作者单位

Department of Biochemistry, University of Lucknow, Lucknow, India;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Apoptosis; Autophagy; Cell survival; Therapeutic resistance; Urothelial carcinoma of bladder;

Emerging roles of autophagy in the development and treatment of urothelial carcinoma of the bladder

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