Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

Wanvisa Udomsinprasert; Abhasnee Sobhonslidsuk; Jiraphun JittikoonSittisak HonsawekUsa Chaikledkaew

首页> 外文期刊>Expert opinion on therapeutic targets >Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

【24h】

Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

机译：Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Introduction: New insights indicate a causative link between cellular senescence and liver fibrosis. Senescent hepatic stellate cells (HSCs) facilitate fibrosis resolution, while senescence in hepatocytes and cholangiocytes acts as a potent mechanism driving liver fibrogenesis. In many clinical studies, telomeres and mitochondrial DNA contents, which are both aging biomarkers, were reportedly associated with a degree of liver fibrosis in patients with chronic liver diseases (CLDs); this highlights their potential as biomarkers for liver fibrogenesis. A deeper understanding of mechanisms underlying multi-step progression of senescence may yield new therapeutic strategies for age-related chronic liver pathologies. Areas covered: This review examines the recent findings from preclinical and clinical studies on mechanisms of senescence in liver fibrogenesis and its involvement in liver fibrosis. A comprehensive literature search in electronic databases consisting of PubMed and Scopus from inception to 31 August 2021 was performed. Expert opinion: Cellular senescence has diagnostic, prognostic, and therapeutic potential in progressive liver complications, especially liver fibrosis. Stimulating or reinforcing the immune response against senescent cells may be a promising and forthright biotherapeutic strategy. This approach will need a deeper understanding of the immune system’s ability to eliminate senescent cells and the molecular and cellular mechanisms underlying this process.

著录项

来源
《Expert opinion on therapeutic targets》 |2021年第12期|799-813|共15页
作者
Wanvisa Udomsinprasert; Abhasnee Sobhonslidsuk; Jiraphun JittikoonSittisak HonsawekUsa Chaikledkaew;
展开▼
作者单位

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类药学;
关键词
Cellular senescence; telomere shortening; mitochondrial dysfunction; liver fibrosis; age-related chronic liver diseases;

Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

摘要

著录项

相关主题

期刊订阅