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首页> 外文期刊>Asian journal of research in chemistry >Spectrophotometric Methods for the Estimation of Cinitapride and Omeprazole in Bulk and Oral Dosage Form
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Spectrophotometric Methods for the Estimation of Cinitapride and Omeprazole in Bulk and Oral Dosage Form

机译：分光光度法估算散装和口服剂量的西尼他必利和奥美拉唑

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摘要

Different UV spectrophotometric methods have been developed for the estimation of Cinitapride (CNP) and omeprazole (OME) in both bulk and capsule dosage form. Both the drugs were well soluble in methanol. CNP and OME showed absorption maximum at 262nm and 301nm respectively using methanol as solvent. Both the drags obeyed Beer's law showing linearity in the range of 4-20μg/ml with correlation coefficient of 1. Method A is the standard absorbance method, method B involves determination of the Area under curve (AUC) and method C and D are the First and Second derivative of the Zero order spectrum respectively. The developed procedures were analyzed for specificity, limit of detection (LOD), limit of quantification (LOQ), linearity of response, precision and accuracy. Thus the proposed method could be adopted for routine analysis of the formulation.
机译：已经开发出了不同的紫外分光光度法来估算散装和胶囊剂型中的Cinitapride（CNP）和奥美拉唑（OME）。两种药物均易溶于甲醇。以甲醇为溶剂，CNP和OME在262nm和301nm处显示最大吸收。两种阻力均符合比尔定律，线性在4-20μg/ ml范围内，相关系数为1。方法A是标准吸光度方法，方法B涉及确定曲线下面积（AUC），方法C和D是零阶谱的一阶和二阶导数。分析开发的程序的特异性，检测限（LOD），定量限（LOQ），响应线性，精确度和准确性。因此，所提出的方法可以用于制剂的常规分析。

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