Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy

Rameep Singh; Pratik Adhya; Shyam Sunder Sharma

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Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy

机译：Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy

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Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) and its related pain is a major side effect of certain chemotherapeutic agents used in cancer treatment. Available analgesics are mostly symptomatic, and on prolonged treatment, patients become refractive to them. Hence, the development of improved therapeutics that act on novel therapeutic targets is necessary. Potential targets include the redox-sensitive TRP channels e.g. TRPA1, TRPC5, TRPC6, TRPM2, TRPM8, TRPV1, TRPV2, and TRPV4 which are activated under oxidative stress associated with CIPN. Areas covered: We have examined numerous neuropathy-inducing cancer chemotherapeutics and their pathophysiological mechanisms. Oxidative stress and its downstream targets, the redox-sensitive TRP channels, together with their potential pharmacological modulators, are discussed. Finally, we reflect upon the barriers to getting new therapeutic approaches into the clinic. The literature search was conducted in PubMed upto and including April 2021. Expert opinion: Redox-sensitive TRP channels are a promising target in CIPN. Pharmacological modulators of these channels have reduced pain in preclinical models and in clinical studies. Clinical scrutiny suggests that TRPA1, TRPM8, and TRPV1 are the most promising targets because of their pain-relieving potential. In addition to the analgesic effect, TRPV1 agonist-Capsaicin possesses a disease-modifying effect in CIPN through its restorative property in damaged sensory nerves.

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《Expert opinion on therapeutic targets》 |2021年第12期|529-545|共17页
作者
Rameep Singh; Pratik Adhya; Shyam Sunder Sharma;
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作者单位

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Chemotherapy; peripheral neuropathy; neuropathic pain; pathophysiological mechanisms; oxidative stress; redoxtrp; pharmacotherapy; chemotherapy-induced peripheral neuropathy; cipn;

Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy

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