The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma

Wang Jiao; Ge Fujing; Yuan TaoQian MeijiaYan FangjieYang BoHe QiaojunZhu Hong

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The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma

机译：The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma

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Introduction Cholangiocarcinoma consists of a cluster of malignant biliary tumors that tend to have a poor prognosis, ranking as the second most prevalent type of liver cancer, and their incidence rate has increased globally recently. The high-frequency driving mutations of cholangiocarcinoma, such as KRAS/IDH1/ARID1A/P53, imply the epigenetic instability of cholangiocarcinoma, leading to the dysregulation of various related transcription factors, thus affecting the occurrence and development of cholangiocarcinoma. Increasingly evidence indicates that the high heterogeneity and malignancy of cholangiocarcinoma are closely related to the dysregulation of transcription factors which promote cell proliferation, invasion, migration, angiogenesis, and drug resistance through reprogrammed transcriptional networks. It is of great significance to further explore and summarize the role of transcription factors in cholangiocarcinoma. Areas covered This review summarizes the oncogenic or tumor suppressive roles of key transcription factors in regulating cholangiocarcinoma progression and the potential targeting strategies of transcription factors in cholangiocarcinoma. Expert opinion Cholangiocarcinoma is a type of cancer highly influenced by transcriptional regulation, specifically transcription factors and epigenetic regulatory factors. Targeting transcription factors could be a potential and important strategy that is likely to impact future cholangiocarcinoma treatment.

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《Expert opinion on therapeutic targets》 |2022年第12期|781-789|共9页
作者
Wang Jiao; Ge Fujing; Yuan TaoQian MeijiaYan FangjieYang BoHe QiaojunZhu Hong;
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作者单位

Westlake Lab Life Sci & Biomed;

Zhejiang University,Zhejiang Univ;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Cholangiocarcinoma; transcription factor; epigenetics; gene mutation; molecular mechanisms; drug target; FLUKE-RELATED CHOLANGIOCARCINOMA; B-CELL FACTOR-1; PROMOTER HYPERMETHYLATION; SIGNAL TRANSDUCER; POOR-PROGNOSIS; EXPRESSION; METASTASIS; CANCER; OVEREXPRESSION; ACTIVATION;

The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma

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