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Dynamic MRI for tumor enhancement: An experimental breast cancer model

机译:动态MRI增强肿瘤:实验性乳腺癌模型

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Dynamic contrast-enhanced magnetic resonance imaging (MRI) with post-processing is routinely used for the analysis of tumors. However, although breast MRI has gained broad clinical recognition, the relationship between imaging findings and tumor pathogenesis has yet to be fully elucidated. We grafted tumors on rats, to examine dynamic MRI images of the tumors, using post-processing subtraction with 3D maximum intensity projection (sMIP). We established a preliminary platform for analysis to compare hemodynamic-based images with histopathological findings and to further biomolecular research. This platform could facilitate future research on the mechanisms of breast tumor enhancement using MRI, improvements to MRI analysis and reduction of the false positive rate, and the development of novel drugs and contrast media.
机译:具有后处理功能的动态对比增强磁共振成像(MRI)通常用于分析肿瘤。然而,尽管乳腺MRI已获得广泛的临床认可,但影像学发现与肿瘤发病机制之间的关系尚未完全阐明。我们将肿瘤移植到大鼠上,使用具有3D最大强度投影(sMIP)的后减法检查肿瘤的动态MRI图像。我们建立了一个初步的分析平台,以比较基于血流动力学的图像与组织病理学发现以及进一步的生物分子研究。该平台可促进有关使用MRI增强乳腺肿瘤的机制,改善MRI分析和减少假阳性率以及开发新药和造影剂的未来研究。

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