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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >Development of peg-containing brush copolymer: Their effect on resistance to protein adsorption behaviors
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Development of peg-containing brush copolymer: Their effect on resistance to protein adsorption behaviors

机译：含钉的刷状共聚物的开发：它们对蛋白质吸附行为的抵抗力

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摘要

Polyethylene glycol (PEG) has been grafted onto surface of many medical devices to reduce or eliminate protein adsorption that often leads to infection or inflammatory responses. Besides commonly used surface activation strategies, here in this work, the novel functional brush copolymer poly (vinyl alcohol)-g-PEG-co-polyurethane (PVA-g-(PEG-co-PU)) was first synthesized, characterized, and evaluated. PVA is used here as a versatile backbone platform for grafting functional molecules. On the one hand, the PU molecules can attach to the surface of desired PU-based implants, on the other hand, the presence of densely grafted PEG at the materials-tissue interface effectively impedes nonspecific protein adsorption. These copolymers with various grafting ratio of PEG and PU were analyzed by Fourier transform infrared spectroscopy and gel permeation chromatography. The brush copolymers that were obtained were further coated on the PU surface and contact angle measurements were performed. It was found that the brush copolymers turn the surface more hydrophilic with increasing PEG grafting density. Furthermore, the effects of PEG ratio on protein adsorption-resistant behavior were investigated. Protein adsorption was found to be the lowest on the surfaces with the highest PEG grafting density on PVA backbone. The study demonstrated unique brush copolymer to work as a potentially useful coating material.
机译：聚乙二醇（PEG）已嫁接到许多医疗设备的表面，以减少或消除经常导致感染或炎症反应的蛋白质吸附。除了常用的表面活化策略外，本文中还首先合成，表征和表征了新型功能性刷式共聚物聚（乙烯醇）-g-PEG-共聚聚氨酯（PVA-g-（PEG-co-PU））。评估。 PVA在这里用作移植功能分子的通用骨架平台。一方面，PU分子可以附着到所需的基于PU的植入物的表面，另一方面，在材料-组织界面处存在密集接枝的PEG有效地阻碍了非特异性蛋白质的吸附。通过傅立叶变换红外光谱和凝胶渗透色谱法分析了这些具有不同接枝率的PEG和PU的共聚物。将获得的刷状共聚物进一步涂覆在PU表面上，并进行接触角测量。发现刷状共聚物随着PEG接枝密度的增加使表面变得更亲水。此外，研究了PEG比对蛋白质吸附抗性行为的影响。发现在PVA主链上具有最高PEG接枝密度的表面上蛋白质吸附最低。该研究表明独特的刷式共聚物可以用作潜在有用的涂料。

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