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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >SYSTEM FOR MEASURING RODENTS' VISUAL FUNCTION: DESIGN AND IMPLEMENTATION
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SYSTEM FOR MEASURING RODENTS' VISUAL FUNCTION: DESIGN AND IMPLEMENTATION

机译：帐篷视觉功能测量系统：设计和实现

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摘要

The aim of the work presented in this paper is the design, manufacturing and assembling of a system able to measure rodents' (mice and rats) visual function and to study the evolution of degenerative retina diseases. Measurement of contrast sensitivity and visual acuity is essential to design new drugs and understand mechanisms of visual development to evaluate treatments' effectiveness. Classical methods to study visual perception of animals such as electro-retinogram (ERG) or histological analysis axe not supplying enough information because connection between eyes and brain is not considered. The system proposed in this work consists of four screens forming a cube with black meth-acrylate plastic floor and roof. Screens display visual stimulus and the rodent's behaviour (placed over a platform in the middle of the cube) is analized to determine its visual acuity and contrast sensitivity. These visual stimuli are generated from a FPGA board designed in this project. This board has a USB link with a computer and it controls screens via VGA signals. Rodents' behaviour is analized using computer vision algorithms under OpenCV libraries. To test the system, more than 30 mice (C57 and RD10 type) have been used to validate the hardware, the software, the procedure and protocol.
机译：本文提出的工作目标是设计，制造和组装能够测量啮齿动物（小鼠和大鼠）视觉功能并研究退化性视网膜疾病演变的系​​统。对比敏感度和视敏度的测量对于设计新药和理解视觉发展机制以评估治疗效果至关重要。研究动物视觉感知的经典方法，例如视网膜电图（ERG）或组织学分析斧，由于没有考虑眼睛和大脑之间的连接，因此无法提供足够的信息。在这项工作中提出的系统由四个屏幕组成，这些屏幕与黑色的甲基丙烯酸酯塑料地板和屋顶形成一个立方体。屏幕显示视觉刺激，并且将啮齿动物的行为（放置在立方体中间的平台上）进行分析，以确定其视觉敏锐度和对比敏感度。这些视觉刺激来自该项目中设计的FPGA板。该开发板具有与计算机的USB链接，并且可通过VGA信号控制屏幕。使用OpenCV库下的计算机视觉算法可以对啮齿动物的行为进行分析。为了测试系统，已经使用了30多只小鼠（C57和RD10型）来验证硬件，软件，过程和协议。

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