• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >AN INNOVATIVE APPLICATION OF COMPUTERIZED CELL IMAGE ANALYSIS IN THE THERAPEUTIC AND CLINICAL FOLLOW UP-QUANTITATIVE EVALUATION OF THE CLINICOPATHOLOGICAL IMPROVEMENT IN A CASE OF CUTANEOUS MASTOCYTOSIS RECEIVING A SERIES OF UVA1 IRRADIATION
【24h】

AN INNOVATIVE APPLICATION OF COMPUTERIZED CELL IMAGE ANALYSIS IN THE THERAPEUTIC AND CLINICAL FOLLOW UP-QUANTITATIVE EVALUATION OF THE CLINICOPATHOLOGICAL IMPROVEMENT IN A CASE OF CUTANEOUS MASTOCYTOSIS RECEIVING A SERIES OF UVA1 IRRADIATION

机译：计算机细胞图像分析在治疗一系列临床研究和临床病理学改善的定量评估中的创新应用，这种情况是在连续的巨噬细胞增生症患者接受一系列UVA1照射的情况下

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The severity and outcome of mastocytosis are known to be related to the number and size of mast cells. The standard treatment of this rare dermatological disorder is phototherapy with UVA1 irradiation. Here, the treatment effects were evaluated during the course of phototherapy on a patient with mastocytosis (urticaria pigmentosa). Photomicrographs of CD117 antibody-stained histological sections of the dermis were analyzed using image software programmed with artificial neural networks. The artificial neural networks analyzed the color feature of epidermis, dermis and mast cells. First, mast cells were isolated from epidermis and dermis, and RGB pixels were converted to HSV color space for artificial neural networks training. Secondly, morphology and connective component labeling were used in epidermal pixels classification to determine the scope of dermal areas. Thirdly, regional separation isolated the dermis for the mast cell analysis. Specifically, the number and size of mast cells were quantified. The method has good reproducibility compared with other methods which had larger variance and lower accuracy. We found also that the UVA1 phototherapy was effective as indicated by a post-treatment change in the ratio of mast cell surface to cell number. In addition, we compared similar results based on subjective visual inspection (from 10 human subjects). Both methods of analysis showed a reduction in the number and size of mast cells after phototherapy. But compared with human judgment, the computerized method was superior in accuracy, sensitivity, specificity and reproducibility of the findings.
机译：肥大细胞增多症的严重程度和预后与肥大细胞的数量和大小有关。这种罕见的皮肤病的标准治疗方法是用UVA1照射进行光疗。在此，在光疗过程中评估了肥大细胞增多症（色素性荨麻疹）患者的治疗效果。使用用人工神经网络编程的图像软件分析CD117抗体染色的真皮组织学切片的显微照片。人工神经网络分析了表皮，真皮和肥大细胞的颜色特征。首先，从表皮和真皮中分离出肥大细胞，并将RGB像素转换为HSV颜色空间以进行人工神经网络训练。其次，在表皮像素分类中使用形态学和结缔组织标记来确定皮肤区域的范围。第三，区域分离分离出用于肥大细胞分析的真皮。具体地，肥大细胞的数量和大小被定量。与其他方差较大，准确度较低的方法相比，该方法具有良好的重现性。我们还发现，肥大细胞表面与细胞数之比的治疗后变化表明，UVA1光疗是有效的。此外，我们比较了基于主观视觉检查（来自10位人类受试者）的相似结果。两种分析方法均显示出光疗后肥大细胞的数量和大小减少。但是与人的判断相比，该计算机化方法在结果的准确性，敏感性，特异性和可重复性方面均优越。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号