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首页> 外文期刊>Bioconjugate Chemistry >Quantum Dots Bearing Lectin-Functionalized Nanoparticles as a Platform for In Vivo Brain Imaging
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Quantum Dots Bearing Lectin-Functionalized Nanoparticles as a Platform for In Vivo Brain Imaging

机译：带有凝集素功能化纳米粒子的量子点作为体内脑成像的平台。

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Delivery of imaging agents to the brain is highly important for the diagnosis and treatment of central nervous system (CNS) diseases, as well as the elucidation of their pathophysiology. Quantum dots (QDs) provide a novel probe with unique physical, chemical, and optical properties, and become a promising tool for in vivo molecular and cellular imaging. However, their poor stability and low blood—brain barrier permeability severely limit their ability to enter into and act on their target sites in the CNS following parenteral administration. Here, we developed a QDs-based imaging platform for brain imaging by incorporating QDs into the core of poly(ethylene glycol)—poly (lactic acid) nanoparticles, which was then functionalized with wheat germ agglutinin and delivered into the brain via nasal application. The resulting nanoparticles, with high payload capacity, are water-soluble, stable, and showed excellent and safe brain targeting and imaging properties. With PEG functional terminal groups available on the nanoparticles surface, this nanoprobe allows for conjugation of various biological ligands, holding considerable potential for the development of specific imaging agents for various CNS diseases.
机译：向大脑中输送成像剂对于中枢神经系统（CNS）疾病的诊断和治疗及其病理生理的阐明非常重要。量子点（QD）提供了一种具有独特物理，化学和光学特性的新型探针，并成为体内分子和细胞成像的有前途的工具。但是，它们的稳定性差和血脑屏障通透性低，严重限制了它们在肠胃外给药后进入中枢神经系统并对其靶位起作用的能力。在这里，我们通过将QDs整合到聚（乙二醇）-聚（乳酸）纳米颗粒的核心中，开发了基于QDs的大脑成像平台，然后将其与小麦胚芽凝集素一起功能化，并通过鼻部应用传递到大脑中。所得的纳米粒子具有高的有效负载能力，是水溶性的，稳定的，并显示出极佳且安全的大脑靶向和成像特性。有了纳米颗粒表面上可用的PEG功能性末端基团，该纳米探针可以缀合各种生物配体，为开发各种CNS疾病的特定显像剂具有巨大的潜力。

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