...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Avian Diseases >Adaptation and Transmission of a Wild Duck Avian Influenza Isolate in Chickens
【24h】

Adaptation and Transmission of a Wild Duck Avian Influenza Isolate in Chickens

机译：鸡野鸭禽流感分离株的适应与传播

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mutations in a wild duck isolate of avian influenza virus were detected in isolates shed by chickens within 1 day after inoculation. The newly adapted virus was transmitted to nave chickens in direct contact and sharing food and water. Two consistent amino acid substitutions in the hemagglutinin have been identified, A198V and S274F, and may be important in transmissibility. Mutants with a 30 amino acid deletion in the neuraminidase stalk region 43-72 (N9 numbering) were recovered from inoculated chickens, but not from naive chickens in contact. The NA stalk mutant virus did not replicate well in Pekin ducks. In vivo viral replication was at low titers and a change in tropism from the respiratory to the digestive tract was observed. Our results indicated that there is a rapid generic adaptation of wild bird isolates in poultry species, but that resultant viruses may have phenotypes that arc intermediate and not fully adapted to the new host.
机译：在接种后1天之内，在由鸡流下的分离株中检测到野鸭分离株的禽流感病毒突变。新适应的病毒通过直接接触并共享食物和水被传播给中殿鸡。血凝素中两个一致的氨基酸取代已被鉴定出来，即A198V和S274F，它们可能对传播具有重要意义。从接种鸡中回收了神经氨酸酶茎区域43-72（N9编号）中具有30个氨基酸缺失的突变体，但未从接触过的雏鸡中回收。 NA茎突变病毒在北京鸭中不能很好地复制。体内病毒复制的滴度很低，并且观察到从呼吸道到消化道的向性变化。我们的结果表明，家禽物种中野生鸟类分离株具有快速的通用适应性，但所得病毒的表型可能处于中间状态，而不能完全适应新宿主。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号