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首页> 外文期刊>Avian Diseases >Astrovirus, reovirus, and rotavirus concomitant infection causes decreased weight gain in broad-breasted white poults.
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Astrovirus, reovirus, and rotavirus concomitant infection causes decreased weight gain in broad-breasted white poults.

机译：星状病毒，呼肠孤病毒和轮状病毒并发感染导致宽胸白家禽体重增加减少。

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Turkey astrovirus type-2 (TAstV-2), turkey rotavirus (TRotV), and turkey reovirus (TReoV) have been implicated as possible causes of enteric diseases and poor production in turkeys; however, numerous studies with each individual virus have failed to reproduce the disease as observed in the field. Therefore, in this study we evaluated the pathogenesis of all possible combinations of one, two, or three viruses in comparison to sham inoculates in 3-day-old turkey poults. Body weights were recorded at 2, 4, 7, 10, and 14 days postinoculation (PI) and were decreased in virus-infected turkeys throughout the experiment as compared to sham inoculates. Although not significantly different from the other virus-exposed groups, the poults exposed to all three viruses had the lowest body weights throughout the experiment. Clinical signs, including huddling, diarrhea, and agitation, were only observed in groups exposed to TAstV-2 and/or TRotV. At 4 days PI, birds from each treatment group were necropsied, and pale intestines with watery contents and undigested feed were observed in the groups that were exposed to TRotV+TReoV or TRotV+TAstV-2 and the group exposed to all three viruses. Minimal microscopic lesions were observed in the intestines of turkeys infected with TAstV-2, TReoV, or a combination of both. In the turkeys infected with TRotV, either alone or in combination with other viruses, mild microscopic lesions were found in all sections of the small intestine and viral antigen was identified by immunohistochemical staining in mature enterocytes. No or very mild lesions were observed in other organs with the exception of the bursa of Fabricius, where mild to severe atrophy was observed in all virus-infected poults examined. Cloacal shedding of TAstV-2 and TRotV was evaluated by reverse-transcription PCR testing of cloacal swabs and minimal differences were observed among the treatment groups.
机译：土耳其2型星状病毒（TAstV-2），火鸡轮状病毒（TRotV）和火鸡呼肠孤病毒（TReoV）被认为是造成肠道疾病和火鸡生产不良的原因。然而，如实地观察到的，对每种病毒的大量研究未能重现该病。因此，在这项研究中，与3天大的火鸡家禽假接种相比，我们评估了一种，两种或三种病毒的所有可能组合的发病机理。在接种后第2、4、7、10和14天记录体重，在整个实验过程中，与假接种相比，病毒感染的火鸡体重下降。尽管与其他暴露于病毒的组没有显着差异，但暴露于所有三种病毒的家禽在整个实验中的体重最低。仅在暴露于TAstV-2和/或TRotV的组中观察到临床症状，包括拥挤，腹泻和躁动。在接种后第4天，对每个处理组的禽进行尸检，在暴露于TRotV + TReoV或TRotV + TAstV-2的组以及暴露于所有三种病毒的组中，观察到浅肠，含水量小，饲料未消化。在感染了TAstV-2，TReoV或两者的组合的火鸡肠中，观察到的显微损伤最小。在单独或与其他病毒组合感染TRotV的火鸡中，在小肠的所有切片中均发现了轻度的微观病变，并通过免疫组化染色在成熟肠上皮细胞中鉴定了病毒抗原。除Fabricius滑囊外，其他器官均未观察到或有非常轻度的损伤，在所有受病毒感染的家禽中均观察到轻度至严重的萎缩。 TAstV-2和TRotV的泄殖腔脱落通过泄殖腔拭子的逆转录PCR测试进行了评估，治疗组之间的差异最小。

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