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首页> 外文期刊>Annual Review of Pharmacology and Toxicology >Drug discovery in the next millennium.
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Drug discovery in the next millennium.

机译：下一个千年的药物发现。

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摘要

Selection and validation of novel molecular targets have become of paramount importance in light of the plethora of new potential therapeutic drug targets that have emerged from human gene sequencing. In response to this revolution within the pharmaceutical industry, the development of high-throughput methods in both biology and chemistry has been necessitated. This review addresses these technological advances as well as several new areas that have been created by necessity to deal with this new paradigm, such as bioinformatics, cheminformatics, and functional genomics. With many of these key components of future drug discovery now in place, it is possible to map out a critical path for this process that will be used into the new millennium.
机译：鉴于人类基因测序中出现了许多新的潜在治疗药物靶标，新型分子靶标的选择和验证变得至关重要。为了响应制药行业的这一革命，必须开发生物学和化学领域的高通量方法。这篇评论论述了这些技术进步以及必须处理这种新范式的几个新领域，例如生物信息学，化学信息学和功能基因组学。现在，有了许多未来药物发现的关键要素，有可能为这一过程规划出一条关键的道路，并将其用于新的千年。

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