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首页> 外文期刊>Annual Review of Phytopathology >Models of Fungicide Resistance Dynamics.
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Models of Fungicide Resistance Dynamics.

机译：杀菌剂抵抗动力学模型。

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We describe two classes of models used for fungicide and antibiotic resistance dynamics. One class assumes that the density of the pathogen (or severity of the disease caused by the pathogen) has no feedback effects on the rate at which new infections arise. The second class does not make this assumption. A quantitative relationship between these two classes is derived. We then discuss the two sets of assumptions made in the literature about initial conditions: either both the fungicide-sensitive strain and the -resistant strain are initially at low density, or the sensitive strain is resident at nonlow density and the resistant strain is initially at low density. We show that models of fungicide resistance dynamics with and without density-dependent feedback give contrasting predictions on the effects of pathogen life-cycle parameters and the effects of the fungicide (dose, frequency, use of mixtures, spatial usage restrictions) on the evolution, invasion, and spread of fungicide resistance. We further show that the evaluation of a resistance management strategy requires a very precise definition of what constitutes a good strategy.
机译：我们描述了用于杀菌剂和抗生素抗药性动力学的两类模型。一类假设病原体的密度（或由病原体引起的疾病的严重程度）对新感染的发生率没有反馈影响。第二类不做这个假设。得出这两个类别之间的定量关系。然后，我们讨论有关初始条件的文献中的两组假设：要么对杀菌剂敏感的菌株和对-抗性的菌株最初处于低密度，要么对敏感菌株驻留在非低密度，而对抗性菌株最初处于低密度。低密度。我们表明，具有和不具有依赖于密度的反馈的杀真菌剂抗药性动力学模型对病原体生命周期参数的影响和杀真菌剂（剂量，频率，混合物的使用，空间使用限制）对进化的影响做出了相反的预测，抗药性的入侵和传播。我们进一步表明，对阻力管理策略的评估需要对构成好的策略的定义非常精确。

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