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首页> 外文期刊>Immunopharmacology and immunotoxicology >Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
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Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.

机译:Jeevaneeya Rasayana的抗炎和抗氧化作用:阿育吠陀多草药制剂,可治疗急性和慢性炎症模型。

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摘要

The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and their anti-inflammatory activity in carrageenan-induced acute model was evaluated. MJR at a dose of 25 mg/kg showed significantly higher anti-inflammatory effect than EJR, WJR, and standard drug diclofenac. MJR also significantly decreased the paw edema in AIA rats. Activities of cyclooxygenase, 5-lipoxygenase, and myeloperoxidase were decreased significantly on treatment with MJR. Supplementation with MJR increases the activities of antioxidant enzymes and the level of glutathione content. The increment in the concentration of C-reactive protein, thiobarbituric acid reactive substance, and ceruloplasmin observed in arthritic rats were found to be significantly restored in MJR treated rats. Thus, the results demonstrated the potential beneficiary effect of methanolic extract of Jeevaneeya Rasayana on acute and chronic models of inflammation.
机译:本研究旨在参考炎症介质建立佐剂性关节炎(AIA)大鼠模型中的阿育吠陀多草药制剂Jeevaneeya Rasayana(JR)的功效。制备了JR的甲醇(MJR),乙醇(EJR)和水提取物(WJR),并评估了它们在角叉菜胶诱导的急性模型中的抗炎活性。剂量为25 mg / kg的MJR表现出比EJR,WJR和标准药物双氯芬酸更高的抗炎作用。 MJR还可以显着降低AIA大鼠的爪水肿。用MJR治疗后,环氧合酶,5-脂氧合酶和髓过氧化物酶的活性显着降低。补充MJR可增加抗氧化酶的活性和谷胱甘肽含量的水平。发现在关节炎大鼠中观察到的C反应蛋白,硫代巴比妥酸反应性物质和铜蓝蛋白的浓度增加在MJR治疗的大鼠中得到了明显恢复。因此,结果证明了Jeevaneeya Rasayana的甲醇提取物对急性和慢性炎症模型的潜在有益作用。

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