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首页> 外文期刊>Immunopharmacology and immunotoxicology >In vivo immunomodulatory effects of aqueous extracts of Larrea divaricata Cav.
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In vivo immunomodulatory effects of aqueous extracts of Larrea divaricata Cav.

机译：Larrea divaricata Cav水提取物的体内免疫调节作用。

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摘要

Several medicinal plants are considered immunomodulatory as they display a variety of anti-inflammatory, antimicrobial and antitumoral effects. Larrea divaricata Cav. (jarilla) (Zygophyllaceae) is a plant widely used in popular medicine to treat tumors, infections, and inflammatory diseases. So far, the immunostimulating activities of Larrea divaricata have not been studied in vivo. In this work, we used healthy mice to assess the immunomodulatory potential of aqueous extracts of Larrea divaricata Cav. We found that Decoction (D) and Infusion (I) from Larrea divaricata Cav showed any acute hepatotoxic activity. Only D at 0.5 mg/kg increased the carrageenan-induced inflammation. Macrophages harvested from treated mice showed no signs of apoptosis. These cells showed a significant increase in NO and TNF-alpha release and exhibited the strongest expression of iNOS. Decoction also increased the phagocytosis of zymosan and the binding of LPS-FITC. The expression of CD14, TLR4 and CR3 was lower in macrophages of mice treated than in controls. Thus, Larrea divaricata was able to prime Mphi in vivo and to induce full activation in vitro. Our finding contribute to characterize the biological activity of Larrea divaricata and to understand the ability of these extracts to enhance immune responses.
机译：几种药用植物被认为具有免疫调节作用，因为它们表现出多种抗炎，抗微生物和抗肿瘤作用。 Larrea divaricata腔。 （jarilla）（Zygophyllaceae）是一种广泛用于流行医学中的植物，用于治疗肿瘤，感染和炎性疾病。迄今为止，尚未在体内研究Larrea divaricata的免疫刺激活性。在这项工作中，我们使用健康的小鼠来评估Larrea divaricata Cav水提取物的免疫调节潜力。我们发现，Larrea divaricata Cav的汤剂（D）和输液（I）表现出任何急性肝毒性活性。只有0.5 mg / kg的D会增加角叉菜胶诱导的炎症。从处理过的小鼠中收获的巨噬细胞没有显示出凋亡的迹象。这些细胞显示NO和TNF-α释放显着增加，并且iNOS的表达最强。煎剂还增加了酵母聚糖的吞噬作用和LPS-FITC的结合。在处理的小鼠巨噬细胞中，CD14，TLR4和CR3的表达低于对照组。因此，Larrea divaricata能够在体内引发Mphi并在体外诱导完全活化。我们的发现有助于表征Larrea divaricata的生物学活性，并了解这些提取物增强免疫反应的能力。

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