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首页> 外文期刊>Immunity >Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling
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Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling

机译：克隆增殖和随机修剪编排淋巴结的血管重构

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Lymph node (LN) expansion during an immune response relies on the transient remodeling of its vasculature. Although the mechanisms driving LN endothelial cell division are beginning to be understood, a comprehensive view of LN endothelial cell dynamics at the single-cell level is lacking. Here, we used multicolored fluorescent fate-mapping models to track the behavior of blood endothelial cells during LN expansion upon inflammation and subsequent return to homeostasis. We found that expansion of the LN vasculature relied on the sequential assembly of endothelial cell proliferative units. This segmented growth was sustained by the clonal proliferation of high endothelial venule (HEV) cells, which act as local progenitors to create capillaries andHEVneo-vessels at the periphery of the LN. Return to homeostasis was accompanied by the stochastic death of pre-existing and neo-synthesized LN endothelial cells. Thus, our fate-mapping studies unravel-at a single-cell level-the complex dynamics of vascular-tree remodeling during LN expansion and contraction.
机译：免疫应答过程中淋巴结（LN）的扩张取决于其脉管系统的瞬时重塑。尽管人们开始了解驱动LN内皮细胞分裂的机制，但仍缺乏在单细胞水平上对LN内皮细胞动力学的全面了解。在这里，我们使用了彩色的荧光命运图谱模型来跟踪LN在炎症和随后的体内平衡恢复过程中扩张时血液内皮细胞的行为。我们发现，LN脉管系统的扩展依赖于内皮细胞增生单位的顺序组装。通过高内皮小静脉（HEV）细胞的克隆增生来维持这种分段的生长，高内皮小细胞（HEV）作为局部祖细胞在LN的外围创建毛细血管和HEVneo血管。回到体内平衡，伴随着原有和新合成的LN内皮细胞的随机死亡。因此，我们的命运图研究在单细胞水平上揭示了LN扩张和收缩过程中血管树重塑的复杂动力学。

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