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首页> 外文期刊>Immunity >Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
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Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

机译：在没有病毒抑制的急性HIV-1感染过程中先天淋巴细胞被不可逆地消耗。

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Innate lymphoid cells (ILCs) play a central role in the response to infection by secreting cytokines crucial for immune regulation, tissue homeostasis, and repair. Although dysregulation of these systems is central to pathology, the impact of HIV-1 on ILCs remains unknown. We found that human blood ILCs were severely depleted during acute viremic HIV-1 infection and that ILC numbers did not recover after resolution of peak viremia. ILC numbers were preserved by antiretroviral therapy (ART), but only if initiated during acute infection. Transcriptional profiling during the acute phase revealed upregulation of genes associated with cell death, temporally linked with a strong IFN acute-phase response and evidence of gut barrier breakdown. We found no evidence of tissue redistribution in chronic disease and remaining circulating ILCs were activated but not apoptotic. These data provide a potential mechanistic link between acute HIV-1 infection, lymphoid tissue breakdown, and persistent immune dysfunction.
机译：先天性淋巴样细胞（ILC）通过分泌对免疫调节，组织稳态和修复至关重要的细胞因子，在感染反应中发挥重要作用。尽管这些系统的失调是病理学的中心，但HIV-1对ILC的影响仍然未知。我们发现在急性病毒性HIV-1感染期间人血中的ILC严重耗尽，并且在达到峰值病毒血症后ILC的数量仍未恢复。 ILC数量通过抗逆转录病毒疗法（ART）保留，但仅在急性感染期间启动时才保留。急性期的转录谱分析显示与细胞死亡相关的基因上调，在时间上与强烈的IFN急性期反应相关，并显示肠屏障破坏。我们没有发现在慢性疾病中组织重新分布的证据，并且剩余的循环ILC被激活但没有凋亡。这些数据提供了急性HIV-1感染，淋巴样组织分解和持续性免疫功能障碍之间的潜在机制联系。

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