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首页> 外文期刊>Indian journal of clinical biochemistry: IJCB >Estimated Oeattnine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients
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Estimated Oeattnine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients

机译：估计的奥替宁清除率，同型半胱氨酸和高敏感性C反应蛋白水平的测定，可早期预测2型糖尿病患者的肾病和动脉粥样硬化风险

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Abstract Type 2 diabetes mellitus (T2D) patients are increased risk for cardiovascular disease (CVD) and chronic kidney disease (CKD). Many studies had demonstrated that CKD is significantly associated with CVD. We aim to indicate the using estimated creatinine clearance (eCrCl), homocysteine (tHcy), and high sensitivity-C-reactive protein (hs-CRP) levels, may have an impact on the interpretation risk for nephropathy and CVD. eCrCl was using the Cockroft-Gault formula, eCrCl levels were stratified according to the Kidney Disease Outcome Quality Initiative definition. We measured serum tHcy, hs-CRP, and the other biochemical variables in 54 T2D patients compared with 40 age matched healthy controls (NDM). T2D patients were significantly lower eCrCl than NDM (P < 0.05). T2D patients also showed significantly higher in tHcy, hs-CRP, and MDA levels than NDM subjects (P < 0.05). The eCrCl was significantly correlated with tHcy and hs-CRP levels in T2D patients (r = -0.504, P < 0.001; r =- 0.282, P = 0.047). eCrCl had an impact on interpretation for CKD, especially in T2D patients. Decrease eCrCl concomitant with increased in tHcy, hs-CRP, and MDA levels may present a higher risk for future diabetic nephropathy and CVD.
机译：摘要2型糖尿病（T2D）患者患心血管疾病（CVD）和慢性肾脏病（CKD）的风险增加。许多研究表明，CKD与CVD显着相关。我们的目的是表明使用估计的肌酐清除率（eCrCl），高半胱氨酸（tHcy）和高敏感性C反应蛋白（hs-CRP）水平，可能会对肾病和CVD的解释风险产生影响。 eCrCl使用的是Cockroft-Gault公式，根据肾脏疾病结果质量倡议的定义对eCrCl的水平进行了分层。与40位年龄相匹配的健康对照（NDM）相比，我们测量了54位T2D患者的血清tHcy，hs-CRP和其他生化变量。 T2D患者的eCrCl明显低于NDM（P <0.05）。 T2D患者的tHcy，hs-CRP和MDA水平也显着高于NDM患者（P <0.05）。 eCrCl与T2D患者的tHcy和hs-CRP水平显着相关（r = -0.504，P <0.001; r =-0.282，P = 0.047）。 eCrCl对CKD的解释有影响，尤其是在T2D患者中。 eCrCl的降低伴随tHcy，hs-CRP和MDA含量的升高可能对将来的糖尿病性肾病和CVD造成更高的风险。

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