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首页> 外文期刊>Indian heart journal >1. Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation. The APPROPRIATE study (ACE inhibitors for potential prevention of the deleterious effects of pulmonary regurgitation in adults with repaired tetralogy of Fallot).
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1. Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation. The APPROPRIATE study (ACE inhibitors for potential prevention of the deleterious effects of pulmonary regurgitation in adults with repaired tetralogy of Fallot).

机译:1.雷米普利修复法洛四联症和肺返流的随机试验。适当的研究(ACE抑制剂可预防法洛四联症的成年患者对肺返流的有害作用的预防)。

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摘要

There is no consensus on optimal medical treatment and timing of pulmonary valve replacement for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and consequent right ventricular (RV) dilatation. This randomised double-blind placebo study from United Kingdom aimed at studying the tolerability of the angiotensin-converting-enzyme (ACE) inhibitor, ramipril and its effect on cardiovascular function in rTOF patients. Clinically, stable rTOF patients with moderate/severe PR were included with 6 months follow-up. Cardiovascular magnetic resonance (CMR), echocardiography, neurohormonal analysis, and objective cardiopulmonary exercise testing were done at baseline and at follow-up.
机译:对于法洛(rTOF)伴有肺返流(PR)和随后的右心室(RV)扩张的法洛(rTOF)患者稳定的修复四联症,关于最佳的药物治疗和肺动脉瓣置换的时机尚无共识。这项来自英国的随机双盲安慰剂研究旨在研究血管紧张素转换酶(ACE)抑制剂雷米普利的耐受性及其对rTOF患者心血管功能的影响。临床上,对稳定/中度/重度PR的rTOF患者进行了6个月的随访。在基线和随访时进行了心血管磁共振(CMR),超声心动图,神经激素分析和客观心肺运动测试。

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