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首页> 外文期刊>Annual Review of Immunology >Osteoimmunology: interplay between the immune system and bone metabolism.
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Osteoimmunology: interplay between the immune system and bone metabolism.

机译：骨免疫学：免疫系统与骨骼代谢之间的相互作用。

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Studies of bone and the immune system have converged in recent years under the banner of osteoimmunology. The immune system is spawned in the bone marrow reservoir, and investigators now recognize that important niches also exist there for memory lymphocytes. At the same time, various factors produced during immune responses are capable of profoundly affecting regulation of bone. Mechanisms have evolved to prevent excessive interference by the immune system with bone homeostasis, yet pathologic bone loss is a common sequela associated with autoimmunity and cancer. There are also developmental links, or parallels, between bone and the immune system. Cells that regulate bone turnover share a common precursor with inflammatory immune cells and may restrict themselves anatomically, in part by utilizing a signaling network analogous to lymphocyte costimulation. Efforts are currently under way to further characterize how these two organ systems overlap and to develop therapeutic strategies that benefit from this understanding.
机译：近年来，在骨免疫学的旗帜下，对骨骼和免疫系统的研究趋于融合。免疫系统在骨髓储库中产生，研究人员现在认识到那里也存在重要的记忆淋巴细胞。同时，免疫反应期间产生的各种因素都能够深刻影响骨骼的调节。已经开发出机制来防止免疫系统过度干扰骨稳态，但是病理性骨丢失是与自身免疫和癌症相关的常见后遗症。骨骼与免疫系统之间也存在发展联系或相似之处。调节骨转换的细胞与炎性免疫细胞共有一个共同的前体，并可能在解剖学上限制自身，部分是通过利用类似于淋巴细胞共刺激的信号网络。当前正在努力进一步表征这两个器官系统如何重叠，并开发得益于这种理解的治疗策略。

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