Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

Jung D; Giallourakis C; Mostoslavsky R; Alt FW

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Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

机译：免疫球蛋白重链基因座V（D）J重组的机制和控制。

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V(D)J recombination assembles antigen receptor variable region genes from component germline variable (V), diversity (D), and joining (J) gene segments. For B cells, such rearrangements lead to the production of immunoglobulin (Ig) proteins composed of heavy and light chains. V(D)J is tightly controlled at the Ig heavy chain locus (IgH) at several different levels, including cell-type specificity, intra- and interlocus ordering, and allelic exclusion. Such controls are mediated at the level of gene segment accessibility to V(D)J recombinase activity. Although much has been learned, many long-standing questions regarding the regulation of IgH locus rearrangements remain to be elucidated. In this review, we summarize advances that have been made in understanding how V(D)J recombination at the IgH locus is controlled and discuss important areas for future investigation.

机译：V（D）J重组从成分种系变量（V），多样性（D）和连接（J）基因片段组装抗原受体可变区基因。对于B细胞，这种重排导致产生由重链和轻链组成的免疫球蛋白（Ig）蛋白。 V（D）J在Ig重链基因座（IgH）受到严格控制，处于几个不同的水平，包括细胞类型特异性，位点间和位点间排序以及等位基因排斥。此类控制介导的V（D）J重组酶活性的基因段可及性水平。尽管已学到很多，但有关IgH基因座重排调控的许多长期存在的问题仍有待阐明。在这篇综述中，我们总结了在了解如何控制IgH基因座上的V（D）J重组方面所取得的进展，并讨论了未来研究的重要领域。

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《Annual Review of Immunology》 |2006年第0期|共30页
作者
Jung D; Giallourakis C; Mostoslavsky R; Alt FW;
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正文语种 eng
中图分类基础医学;
关键词
Joule; Unit of energy; IgH locus; Mechanism;

机译：焦耳;能量单位;IgH基因座;机制;

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专利

1. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. [J] . Jung D, Giallourakis C, Mostoslavsky R, Annual Review of Immunology . 2006,第0期

机译：免疫球蛋白重链基因座V（D）J重组的机制和控制。
2. The genetic control of the immune response to staphylococcal nuclease VI. Recombination between genes determining the A/J anti-nuclease idiotypes and the heavy chain allotype locus. [J] . D S Pisetsky, D H Sachs The Journal of Experomental Medicine . 1977,第6期

机译：对葡萄球菌核酸酶VI免疫应答的遗传控制。确定A / J抗核酸酶独特型和重链同种异型基因座的基因之间的重组。
3. IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer [J] . Hussein Issaoui, Nour Ghazzaui, Alexis Saintamand, 细胞与分子免疫学：英文版 . 2017,第010期
4. Minimal Residual Disease In Multiple Myeloma By LC-MS/MS Analysis Of Immunoglobulin Heavy And Light Chain CDR Tryptic Peptides [C] . Linda M. Benson, Angela Dispenzieri, David Murray, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：通过LC-MS / MS分析免疫球蛋白重链CDR胰蛋白酶蛋白的LC-MS / MS分析，在多发性骨髓瘤中最小的残留疾病
5. 'Ups and downs' of the immunoglobulin heavy chain locus. [D] . Chowdhury, Dipanjan. 2003

机译：免疫球蛋白重链基因座的“起伏”。
6. Detection of gene targeting by co-conversion of a single nucleotide change during replacement recombination at the immunoglobulin mu heavy chain locus. [O] . A J Smith, B Kalogerakis 1991

机译：通过在免疫球蛋白mu重链基因座的置换重组过程中单核苷酸变化的共转化来检测基因靶向。
7. Copy choice mechanism of immunoglobulin heavy-chain switch recombination. [O] . Dunnick, W, Stavnezer, J 1990

机译：免疫球蛋白重链开关重组的复制选择机制。

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

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